PMID: 8968625Dec 1, 1996Paper

An investigation of motor function in schizophrenia using transcranial magnetic stimulation of the motor cortex

The British Journal of Psychiatry : the Journal of Mental Science
B K PuriS W Lewis

Abstract

In this first investigation of motor function in schizophrenia using transcranial magnetic stimulation (TMS), the general hypothesis tested was that this methodology could be used to investigate the disruption of corticospinal inhibitory processes suggested by cognitive and psychophysiological paradigms. Nine drug-free DSM-IV schizophrenic patients were compared with nine age- and sex-matched normal subjects. Electromyographic (EMG) recordings were made from the thenar muscles of the dominant hand during sustained, weak voluntary contraction. TMS over a particular threshold applied to the motor cortex would elicit a compound motor evoked potential (cMEP) followed by a period of suppression of EMG. The latency of cMEPs following TMS was significantly shorter in the schizophrenic patients. The two groups did not differ significantly with respect to mean latency of suppression of EMG activity, or stimulus thresholds for either cMEPs or EMG suppression. These findings could be the result of a relative lack of corticospinal inhibition of motor responses; a change in the site of TMS activation; or an abnormality of peripheral nervous function in schizophrenia. Drug effects were unlikely since seven of the patients were drug-naive.

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Citations

Dec 22, 2004·Journal of Magnetic Resonance Imaging : JMRI·Zu Y ShanWilburn E Reddick
Dec 21, 2000·Current Psychiatry Reports·M S GeorgeN Oliver
Mar 10, 2004·Psychiatry Research·Kate E HoyNellie Georgiou-Karistianis
Sep 18, 2004·Schizophrenia Research·H Magnus HaraldssonGiulio Tononi
Jun 25, 2002·Biological Psychiatry·Alvaro Pascual-LeoneDonald C Goff
Jul 2, 2003·Psychiatry Research·Paul B FitzgeraldJayashri Kulkarni
Feb 27, 2004·Schizophrenia Research·Peter EichhammerGöran Hajak
Jul 15, 2003·Neurosurgery Clinics of North America·Mark S GeorgeBenjamin D Greenberg
Mar 4, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·L S Boylan, H A Sackeim
Apr 12, 2002·Acta Psychiatrica Scandinavica·P B FitzgeraldZ J Daskalakis
Sep 13, 2002·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Elisabeth ChroniStavroula Beratis
Jun 1, 2006·Neuropsychiatric Disease and Treatment·Gin S MalhiPerminder Sachdev
Sep 29, 2011·Brain Stimulation·Alkomiet HasanThomas Wobrock
Mar 6, 2010·Psychiatry Research·Evanthia SoubasiPanayiotis Papathanasopoulos
May 27, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kate E HoyPaul B Fitzgerald
Oct 19, 2006·Neurophysiologie clinique = Clinical neurophysiology·G SabaM Leboyer
Dec 3, 2014·Schizophrenia Research·Yingying TangJijun Wang
Jul 25, 2013·Medical Image Analysis·Krzysztof Chris CiesielskiJayaram K Udupa
May 6, 2014·Schizophrenia Research·Elmar FrankBerthold Langguth
May 21, 2005·The Journal of ECT·Humberto Quintana
Mar 17, 2001·Nature Reviews. Neuroscience·V Walsh, A Cowey
May 29, 2000·The British Journal of Psychiatry : the Journal of Mental Science·N J Davey, B K Puri
May 2, 2000·The British Journal of Psychiatry : the Journal of Mental Science·B BoroojerdiU Meincke
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Aug 2, 2003·CNS Spectrums·Mark S GeorgeDaryl E Bohning
Jul 27, 2000·Annals of the New York Academy of Sciences·S E Arnold

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