PMID: 9530981Apr 8, 1998Paper

An investigation of the mechanism of flux across polydimethylsiloxane membranes by use of quantitative structure-permeability relationships

The Journal of Pharmacy and Pharmacology
M T CroninG P Moss

Abstract

Quantitative structure-permeability relationships (QSPRs) based on readily calculated parameters have been developed to study penetration across a polydimethylsiloxane membrane. Maximum steady-state flux values for 256 compounds through a polydimethylsiloxane membrane were taken from previous studies. Forty-three physicochemical parameters were calculated for each compound and their significance to flux determined. Removal of fourteen outliers enabled derivation of a significant three-parameter QSPR based on the number of hydrogen-bond acceptor and donor groups and sixth-order path molecular connectivity. Models based on parameters important for penetration across human skin (log P and molecular weight) were comparatively poor. This model suggests that the mechanism of flux across a polydimethylsiloxane membrane is based mainly on hydrogen-bonding effects; as such it occurs via a mechanism of action different from that of penetration of the skin in man.

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Citations

Sep 5, 2003·Advanced Drug Delivery Reviews·Fumiyoshi Yamashita, Mitsuru Hashida
Jul 27, 2001·Journal of Pharmaceutical and Biomedical Analysis·S Agatonovic-KustrinA P Yusof
May 22, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G P MossM T D Cronin
Feb 11, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M T CroninG Murray-Dickson
Jan 25, 2013·Therapeutic Delivery·Kenneth B SloanHemamalini Ketha
Sep 24, 2009·International Journal of Pharmaceutics·Yanjun ZhaoStuart A Jones
May 12, 2009·International Journal of Pharmaceutics·Scott C WasdoK B Sloan
Jul 1, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Scott WasdoKenneth B Sloan
Feb 3, 2006·The Journal of Pharmacy and Pharmacology·Gary P MossW John Pugh
Aug 17, 2005·International Journal of Pharmaceutics·Gul M KhanVictor M Meidan
Sep 18, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael S La SalaCedrick D Dotson
Apr 15, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ana P SilvaJoão O Malva
Dec 15, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ana P SilvaJoão O Malva
Apr 3, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hideki YuzurihaMineko Fujimiya
Sep 22, 2007·Journal of Receptor and Signal Transduction Research·Ralf ZiemekArmin Buschauer
Apr 5, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brigitta ButtariRachele Riganò
Jan 7, 2003·Alternatives to Laboratory Animals : ATLA·Bas J Blaauboer
May 1, 2000·Alternatives to Laboratory Animals : ATLA·A P Worth, M T Cronin

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