An investigation of the role of ganglia in the innervation of the rat anococcygeus muscle: an electrical and mechanical study

British Journal of Pharmacology
H C McKirdy, T C Muir

Abstract

1 A preparation is described which allows the rat anococcygeus muscle to be stimulated via its two extrinsic nerves. Each nerve contains both excitatory and inhibitory fibres. A ganglionated nerve plexus lies on the surface of the muscle. 2 The possibility that at least part of the excitatory pathway was interrupted as a ganglion synapse lying in one of the nodes of plexus close to the muscle was suggested by the observations that (a) the excitatory response to extrinsic nerve stimulation was reduced by the nicotinic antagonists tubocurarine (0.13 to 0.26 mM) and dihydro beta-erythroidine (0.1 to 0.14 mM). (b) Fibres from one extrinsic nerve were shown to synapse on a ganglion cell from which intracellular recordings were made while the output from this ganglion cell was traced microscopically to the muscle. 3 Intracellular recording from ganglion cells in this plexus indicated that cholinergic synaptic transmission occurred in these ganglia. Tubocurarine (0.13 mM) and hexamethonium (1.3 mM) reversibly abolished intracellularly-recorded synaptic potentials. 4 Hexamethonium (0.1 to 1 mM) initially enhanced the motor response to nerve stimulation and raised muscle tone, probably by an action involving pre- and postsynaptic sites....Continue Reading

References

Feb 1, 1975·The Journal of Physiology·K E CreedT C Muir
Jan 1, 1975·The Journal of Physiology·C T Kirkpatrick
Jan 1, 1974·Cell and Tissue Research·J S Gillespie, R Lüllmann-Rauch
Jun 1, 1973·The Journal of Physiology·S Nishi, R A North
Jul 1, 1972·British Journal of Pharmacology·J S Gillespie
Dec 1, 1971·The Journal of Physiology·P J CrowcroftJ H Szurszewski
Jul 1, 1963·The Journal of Physiology·J G BLACKMANC RAY
Jan 1, 1974·The Journal of Physiology·G D HirstI Spence

Citations

Jan 1, 1990·Cell and Tissue Research·W G DailG Walton
Feb 1, 1992·Clinical and Experimental Pharmacology & Physiology·M J Rand, C G Li
Sep 1, 1987·British Journal of Pharmacology·T C CunnaneK A Wardle
Jan 1, 1983·British Journal of Pharmacology·J A Smith, T L Spriggs

Related Concepts

Nerve Impulses
Metazoa
Electric Stimulation Technique
Ganglia
Hexamethonium Compounds
Resting Potentials
Inotropism
Muscle
Rats, Laboratory
In Vitro [Publication Type]

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