An investigation of toxicities and survival in Hispanic children and adolescents with ALL: Results from the Dana-Farber Cancer Institute ALL Consortium protocol 05-001

Pediatric Blood & Cancer
Justine M KahnKara M Kelly

Abstract

This study compared the relative incidence of treatment-related toxicities and the event-free and overall survival between Hispanic and non-Hispanic children undergoing therapy for acute lymphoblastic leukemia (ALL) on Dana-Farber Cancer Institute ALL Consortium protocol 05-001. Secondary analysis of prospectively collected data from a phase III multicenter study in children and adolescents of 1-18 years with previously untreated ALL. Between 2005 and 2011, 794 eligible patients enrolled on DFCI 05-001, 730 of whom were included in this analysis (19% [N = 150] Hispanic, 73% [N = 580] non-Hispanic). Hispanic patients were more likely to be ≥10 years of age (32% vs. 24%, P = 0.045) at diagnosis. Toxicity analyses revealed that Hispanic patients had significantly lower cumulative incidence of bone fracture (P < 0.001) and osteonecrosis (ON; P = 0.047). In multivariable risk regression, the risk of ON was significantly lower in Hispanic patients ≥10 years (HR 0.23; P = 0.006). Hispanic patients had significantly lower 5-year event-free survival (EFS) (79.4%; 95% CI: 71.6-85.2) and overall survival (OS) (89.2%; 95% CI: 82.7-93.4) than non-Hispanic patients (EFS: 87.5%; 95% CI: 84.5-90.0, P = 0.004; OS: 92.7%; 95% CI: 90.2-94.6, P = ...Continue Reading

Associated Clinical Trials

Nov 17, 2006·Lewis B. Silverman, M.D., Lewis B. Silverman, M.D.

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Citations

Oct 5, 2018·CA: a Cancer Journal for Clinicians·Kimberly D MillerRebecca L Siegel
Sep 10, 2020·British Journal of Cancer·Valentina A ZavalaLaura Fejerman
Sep 21, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Justine M KahnSharon M Castellino
May 11, 2019·Current Hematologic Malignancy Reports·Lena E Winestone, Richard Aplenc
Oct 28, 2019·Pharmacogenetics and Genomics·Guilherme Suarez-KurtzSandro José de Sousa
May 20, 2021·International Journal of Hematology·Yuki ArakawaKatsuyoshi Koh
Sep 22, 2021·CA: a Cancer Journal for Clinicians·Kimberly D MillerRebecca L Siegel
Nov 3, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sara B LeidyKellie J Weddle

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