PMID: 9535243Apr 16, 1998Paper

An investigation of vancomycin-resistant Enterococcus faecium within the pediatric service of a large urban medical center

The Pediatric Infectious Disease Journal
D F McNeeleyH De Lencastre

Abstract

Between 1990 to 1992 and 1993 to 1995 there was a >5-fold increase (16.7% to 89.8%) in vancomycin-resistant Enterococcus faecium isolates as a percentage of all isolates of vancomycin-resistant enterococci on the pediatric units of The New York Hospital-Cornell Medical Center (NYH-CMC). A molecular epidemiologic investigation was undertaken to determine the extent to which this increase was associated with the spread of a vanA-containing clone of vancomycin-resistant E. faecium that had been previously defined in adults hospitalized at NYH-CMC or with the spread of another vanA clone that had been defined in children hospitalized on the pediatric service at Memorial Sloan-Kettering Cancer Center, which shares a common pediatric intensive care unit and pediatric house staff with NYH-CMC. Molecular genotyping of vancomycin-resistant E. faecium isolates obtained from pediatric patients from 1993 to 1995 was performed by pulsed field gel electrophoresis of chromosomal SmaI digests. Southern hybridization was performed using vanA- and vanB-specific probes. Medical records of patients were reviewed for pertinent clinical and demographic information. A single vanB clone of vancomycin-resistant E. faecium was responsible for 17 (77.3%)...Continue Reading

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Citations

Jan 11, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R PatelR L Thompson
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M K Hayden
Sep 10, 2003·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Laszlo PappMirjana Nesin
Aug 4, 1999·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·H de LencastreA Tomasz
Aug 5, 2000·The Pediatric Infectious Disease Journal·D F McNeeleyG J Noel
Oct 13, 2005·The Pediatric Infectious Disease Journal·Craig H RaskindPatrick G Gallagher
Jul 20, 2004·Clinical Microbiology Reviews·David Kaufman, Karen D Fairchild
Mar 19, 2002·Emerging Infectious Diseases·Susan S HuangArthur L Reingold
Feb 24, 2007·Seminars in Perinatology·Matthew J Bizzarro, Patrick G Gallagher
Jun 29, 2001·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·M E RuppL Chapman
Apr 20, 2002·Current Opinion in Infectious Diseases·M Neely, P Toltzis
Jul 8, 1999·Acta Clinica Belgica·J Levy
Sep 3, 2004·Pediatrics·Katherine M SheaUNKNOWN American Academy of Pediatrics Committee on Infectious Diseases
Oct 3, 2002·Pediatrics·Lorry G RubinUNKNOWN Pediatric Prevention Network

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