An Investigation on the Effect of Polyethylene Oxide Concentration and Particle Size in Modulating Theophylline Release from Tablet Matrices

AAPS PharmSciTech
Saeed ShojaeeAli Nokhodchi

Abstract

Polyethylene oxide has been researched extensively as an alternative polymer to hydroxypropyl methylcellulose (HPMC) in controlled drug delivery due to its desirable swelling properties and its availability in a number of different viscosity grades. Previous studies on HPMC have pointed out the importance of particle size on drug release, but as of yet, no studies have investigated the effect of particle size of polyethylene oxide (polyox) on drug release. The present study explored the relationship between polymer level and particle size to sustain the drug release. Tablets produced contained theophylline as their active ingredient and consisted of different polyethylene oxide particle size fractions (20-45, 45-90, 90-180 and 180-425 μm). It was shown that matrices containing smaller particle sizes of polyox produced harder tablets than when larger polyox particles were used. The release studies showed that matrices consisting of large polyox particles showed a faster release rate than matrices made from smaller particles. Molecular weight (MW) of the polymer was a key determining step in attaining sustained release, with the high MW of polyox resulting in a delayed release profile. The results showed that the effect of partic...Continue Reading

References

Apr 27, 1984·Pharmaceutisch Weekblad. Scientific Edition·P De Haan, C F Lerk
Aug 1, 1995·Journal of Pharmaceutical Sciences·P ColomboN A Peppas
Mar 1, 1995·Journal of Pharmaceutical Sciences·C J Kim
Dec 24, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·M V VelascoA R Rajabi-Siahboomi
Mar 5, 1999·Drug Development and Industrial Pharmacy·S Sabnis, C M Adeyeye
May 8, 1999·Pharmaceutical Development and Technology·F Zhang, J W McGinity
Oct 16, 1999·International Journal of Pharmaceutics·M Dimitrov, N Lambov
Jun 7, 2000·Pharmaceutical Science & Technology Today·P ColomboN A Peppas
Sep 5, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·P W HengX Li
Feb 1, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ning WuYi-Yan Yang
Dec 21, 2005·International Journal of Pharmaceutics·Celine Valeria LiewPaul Wan Sia Heng
Nov 19, 2008·AAPS PharmSciTech·Praveen S Hiremath, Ranendra N Saha
Mar 2, 2010·Colloids and Surfaces. B, Biointerfaces·Harikrishna BoyapallyDennis Douroumis
Mar 25, 2014·Current Drug Delivery·Ali Al-KhattawiAfzal R Mohammed

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