An iron regulatory gene signature in breast cancer: more than a prognostic genetic profile?

Future Oncology
Andrea NicoliniAlessandro Antonelli

Abstract

Miller LD, Coffman LG, Chou JW et al. An iron regulatory gene signature predicts outcome in breast cancer. Cancer Res. 71(21), 6728-6737 (2011). In breast cancer, recent progress in technology has enabled us to define different prognostic genetic signatures. Based upon them, breast tumors have been grouped into the four principal categories: basal-like or triple-negative, erbB2-positive, normal-like, and luminal type (A and B); with luminal types sharing the expression of estrogen receptor- and/or progesterone receptor-related genes and, basal-like and erbB2-positive subgroups associated with worse prognosis. So far, Oncotype DX(®) (Genomic Health Inc., Redwood City, CA, USA), Mammaprint(®) (Agendia Inc, Huntington Beach, CA, USA), the Breast Cancer Index(®) (BCI, Biotheranostics, San Diego, CA, USA) and PAM50 (Expression Analysis Inc., Durham, NC, USA) are the only multigene assays that have been marketed in North America and Europe. However, any genetic signature assay still has to gain acceptance as a validated assay before introduction into current clinical practice. This study describes an iron regulatory gene signature (IRGS) in breast cancer associated with clinical outcome. Within the molecular luminal type, the IRGS pr...Continue Reading

References

Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
May 10, 2005·The Journal of Biological Chemistry·Richard A Jungmann, Olga Kiryukhina
Apr 22, 2006·Breast Cancer Research : BCR·Laurent PerreardPhilip S Bernard
Jun 19, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jul 25, 2009·Nature Reviews. Cancer·Janelle M HoskinsHoward L McLeod
Dec 1, 2007·Biomarkers in Medicine·Andrea NicoliniPaolo Miccoli
Nov 18, 2010·BMC Cancer·Eldrid BorganIngrid S Gribbestad
Jan 20, 2011·Neoplasia : an International Journal for Oncology Research·Pankaj SethVikas P Sukhatme
Mar 23, 2011·PloS One·Xi ZhaoOle Christian Lingjærde
Mar 24, 2011·The Cancer Journal·Natalie GalaninaLyndsay N Harris
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Aug 31, 2011·Cancer Research·Lance D MillerFrank M Torti
Sep 29, 2011·Breast Cancer Research and Treatment·Kazuma KiyotaniHitoshi Zembutsu
Oct 11, 2011·Cancer Discovery·Rachel BroughAlan Ashworth

❮ Previous
Next ❯

Citations

Oct 22, 2013·Cancer Treatment Reviews·Nadia HarbeckSophie Doisneau-Sixou

❮ Previous
Next ❯

Methods Mentioned

BETA
reverse-transcription PCR

Software Mentioned

CAERUS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.