An ischemic stroke during intravenous recombinant tissue plasminogen activator infusion for evolving myocardial infarction

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
G Y Chang

Abstract

A 56-year-old man without a previous history of stroke received intravenous recombinant tissue plasminogen activator (tPA) for an evolving myocardial infarction. During the infusion, the patient developed aphasia and right hemiparesis. The CT and MRI confirmed an ischemic stroke without evidence of hemorrhage. Although the cerebral hemorrhage after tPA infusion is relatively more common, in rare cases, tPA infusion may result in fragmentation of a cardiac thrombus resulting in an ischemic cerebral stroke.

References

Jul 1, 1992·Annals of Neurology·G J del ZoppoO Busse
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
May 7, 1999·Stroke; a Journal of Cerebral Circulation·T MooeP Eriksson

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Citations

Dec 8, 2007·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M MehdirattaP A Teal
Dec 27, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Gul Yalcin-CakmakliTurgay Dalkara
Sep 25, 2018·The Neurohospitalist·Gregory Y Chang

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