An isoform of ferritin as a component of protein yolk platelets in Schistosoma mansoni

Molecular Reproduction and Development
P SchüsslerW Kunz

Abstract

Schistosoma mansoni possesses two isoforms of the iron storage protein ferritin, Fer1 and Fer2. At the mRNA level as well as at the protein level, Fer1 is much more abundant than Fer2; females contain an about 15-fold excess of Fer1 compared with males. In contrast, nearly equal amounts of Fer2 occur in both sexes. By electron microscopy we identified ferritin as a component of electron dense membrane-bound bodies in cells of the vitellarium. The mode of formation of these inclusions (as inferred from electron microscopy) and the abundance of phospholipid multilayered membranes suggest that these bodies are of a lysosomal nature. Here we interpret these ferritin-containing inclusions as protein yolk platelets. To date, most of the literature does not contain any hints of the existence of protein yolk in trematodes. The possible function of ferritin in embryonic development is discussed.

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Citations

Feb 19, 2002·Molecular and Biochemical Parasitology·Volker WipperstegChristoph G Grevelding
Jul 28, 2009·Annual Review of Genomics and Human Genetics·Ze-Guang HanZhu Chen
Dec 28, 2007·PLoS Neglected Tropical Diseases·Malcolm K Jones, Julie Balen
Nov 26, 2010·PLoS Neglected Tropical Diseases·Amber GlanfieldMalcolm K Jones
Feb 22, 2012·PLoS Neglected Tropical Diseases·Julien PortelaAnne Robert
May 23, 2013·PLoS Neglected Tropical Diseases·Stephan KarlMalcolm K Jones
Aug 13, 2013·PLoS Neglected Tropical Diseases·Steffen HahnelThomas Quack
Feb 20, 2007·The Journal of Parasitology·Yi TangSung-Jong Hong
May 6, 2009·Development Genes and Evolution·Arnon D JurbergHenrique L Lenzi
Jan 14, 2012·Molecular and Biochemical Parasitology·Kimberly Cabán-HernándezAna M Espino
Jul 14, 2010·Parasitology International·Céline LevronTomáš Scholz
Jun 9, 2007·The International Journal of Biochemistry & Cell Biology·Malcolm K JonesGeoffrey N Gobert
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Oct 27, 2007·Trends in Parasitology·Amber GlanfieldMalcolm K Jones
Jan 25, 2011·Experimental Parasitology·Leigh SchulteMalcolm K Jones
Jul 23, 2013·Molecular & Cellular Proteomics : MCP·Angel P DizDavid O F Skibinski
May 7, 2020·PLoS Neglected Tropical Diseases·Arporn WangwiwatsinMatthew Berriman

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