PMID: 9539801May 16, 1998Paper

An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons

Proceedings of the National Academy of Sciences of the United States of America
A SautterMartin Biel

Abstract

Sensory transduction in olfactory neurons involves the activation of a cyclic nucleotide-gated (CNG) channel by cAMP. Previous studies identified a CNG channel alpha subunit (CNG2) and a beta subunit (CNG5), which when heterologously expressed form a channel with properties similar but not identical to those of native olfactory neurons. We have cloned a new type of CNG channel beta subunit (CNG4. 3) from rat olfactory epithelium. CNG4.3 derives from the same gene as the rod photoreceptor beta subunit (CNG4.1) but lacks the long, glutamic acid-rich domain found in the N terminus of CNG4.1. Northern blot and in situ hybridization revealed that CNG4.3 is expressed specifically in olfactory neurons. Expression of CNG4.3 in human embryonic kidney 293 cells did not lead to detectable currents. Coexpression of CNG4.3 with CNG2 induced a current with significantly increased sensitivity for cAMP whereas cGMP affinity was not altered. Additionally, CNG4.3 weakened the outward rectification of the current in the presence of extracellular Ca2+, decreased the relative permeability for Ca2+, and enhanced the sensitivity for L-cis diltiazem. Upon coexpression of CNG2, CNG4.3, and CNG5, a conductance with a cAMP sensitivity greater than that o...Continue Reading

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Citations

Oct 6, 2007·Molecular Neurobiology·Martin Biel, Stylianos Michalakis
Jun 1, 2005·Current Opinion in Neurobiology·Jonathan BradleyStephan Frings
Aug 17, 1999·Current Opinion in Neurobiology·A Menini
Jun 15, 2004·Nature Neuroscience·Jonathan BradleyStephan Frings
Sep 19, 2006·The Journal of Biological Chemistry·Stylianos MichalakisMartin Biel
Jun 3, 1999·The Journal of General Physiology·S Frings
Nov 26, 2003·The Journal of General Physiology·R Lane BrownReza Arsanjani
Aug 18, 2004·The Journal of General Physiology·Matthew C Trudeau, William N Zagotta
Jan 7, 1999·The EMBO Journal·C DzejaS Frings
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Aug 27, 2013·PloS One·Paige A WinklerSimon M Petersen-Jones
Jan 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sabine HüttlMartin Biel
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·M E GrunwaldK W Yau
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Sep 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Rong-Chang LiChih-Chun Lin
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May 12, 2004·Neuron·Jie Zheng, William N Zagotta
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