An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages.

Antimicrobial Agents and Chemotherapy
Tatiany J de FariaAndré Báfica

Abstract

Nanoenabled drug delivery systems against tuberculosis (TB) are thought to control pathogen replication by targeting antibiotics to infected tissues and phagocytes. However, whether nanoparticle (NP)-based carriers directly interact with Mycobacterium tuberculosis and how such drug delivery systems induce intracellular bacterial killing by macrophages is not defined. In the present study, we demonstrated that a highly hydrophobic citral-derived isoniazid analogue, termed JVA, significantly increases nanoencapsulation and inhibits M. tuberculosis growth by enhancing intracellular drug bioavailability. Importantly, confocal and atomic force microscopy analyses revealed that JVA-NPs associate with both intracellular M. tuberculosis and cell-free bacteria, indicating that NPs directly interact with the bacterium. Taken together, these data reveal a nanotechnology-based strategy that promotes antibiotic targeting into replicating extra- and intracellular mycobacteria, which could actively enhance chemotherapy during active TB.

References

Feb 1, 1994·Thorax·D Honeybourne
Feb 11, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·T GovenderS S Davis
Feb 27, 2003·Antimicrobial Agents and Chemotherapy·Jacques Grosset
Mar 17, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E Nuermberger, J Grosset
Dec 20, 2005·Tuberculosis·Kris L HelkeYukari C Manabe
Oct 27, 2006·FEMS Microbiology Letters·Claire VerbelenYves F Dufrêne
May 3, 2007·PLoS Medicine·Ulrich E Schaible, Stefan H E Kaufmann
Nov 29, 2007·Pflügers Archiv : European journal of physiology·David AlsteensYves F Dufrêne
Dec 22, 2007·Pathology, Research and Practice·Almério L L de NoronhaManoel Barral-Netto
Apr 1, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Xiangrong SongQiuhong Chen
Apr 9, 2008·Current Medicinal Chemistry·Nageshwar R BudhaBernd Meibohm
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Oct 9, 2008·Drug Discovery Today·Emma C Rivers, Ricardo L Mancera
May 26, 2009·Journal of Bacteriology·Omar H VandalSabine Ehrt
Jun 6, 2009·Cellular and Molecular Life Sciences : CMLS·Hervé Hillaireau, Patrick Couvreur
Jun 16, 2009·European Journal of Medicinal Chemistry·Michael J HearnRebecca Wilson
Aug 15, 2009·Expert Opinion on Drug Delivery·Paolo BlasiMaurizio Ricci
Oct 15, 2009·International Journal of Pharmaceutics·C E Mora-HuertasA Elaissari
Nov 17, 2009·Advanced Drug Delivery Reviews·Alejandro SosnikDiego A Chiappetta
May 11, 2010·Current Opinion in Chemical Biology·Clifton E Barry, John S Blanchard
May 15, 2010·Science·David G RussellJoAnne L Flynn
May 15, 2010·Science·Christopher Dye, Brian G Williams
Aug 3, 2010·Nature Reviews. Microbiology·Samuel M BeharHeinz G Remold
Oct 13, 2010·Nature Reviews. Microbiology·Gareth GriffithsGopal K Khuller
Oct 20, 2010·International Journal of Nanomedicine·Rama Mallipeddi, Lisa Cencia Rohan
Jan 29, 2011·Nature·Anil KoulKoen Andries
Feb 19, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Rajesh Pandey, Zahoor Ahmad
May 23, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·D Mitchison, G Davies

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Citations

Dec 22, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yihua Pei, Yoon Yeo
Jun 10, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yolandy LemmerChantal de Chastellier
Jun 1, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shuyu XieZonghui Yuan
Aug 15, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Benson J EdagwaPrabagaran Narayanasamy
Nov 18, 2018·Journal of Interdisciplinary Nanomedicine·Lai JiangChristopher J Scott
Jun 21, 2019·Current Pharmaceutical Design·Prasad MinakshiGaya Prasad
May 12, 2020·Frontiers in Microbiology·Yuan LiuZhiqiang Wang
Mar 21, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Maria Hassan KianiGul Shahnaz
Mar 27, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Young H LimKaren L Wooley
Jan 14, 2021·Nanomaterials·John Jairo Aguilera-CorreaMaría Vallet-Regí
Dec 6, 2020·Journal of Veterinary Pharmacology and Therapeutics·Zhiqun Lei, Aman Karim
Jun 1, 2021·Frontiers in Chemistry·M Mustafa MamunEric P Vejerano
Feb 21, 2019·Biomacromolecules·Jiří TrousilMartin Hrubý

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