An L-arginine-derived factor mediates endotoxin-induced vascular hyposensitivity to calcium

European Journal of Pharmacology
G A GrayJ C Stoclet

Abstract

Aortas removed from rats treated with bacterial endotoxin displayed a reduced sensitivity to calcium (CaCl2, 10 microM-10 mM) in depolarizing medium (100 mM K+). Sensitivity was reduced further in the presence of L-arginine (1 mM) but restored to control by N omega-nitroarginine methyl ester (L-NAME, 300 microM) or NG-monomethyl-L-arginine (L-NMMA, 300 microM), inhibitors of nitric oxide synthesis from L-arginine. Furthermore, addition of methylene blue (10 microM), an inhibitor of soluble guanylate cyclase, restored the contractile response to 10 mM CaCl2. The results suggest that vascular hyposensitivity to calcium involves stimulation of guanylate cyclase subsequent to activation of the L-arginine pathway by endotoxin.

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Citations

Mar 24, 2004·International Immunopharmacology·Victor M VictorMonica De la Fuente
May 1, 1997·Disease-a-month : DM·R G KilbournC Szabó
Aug 12, 1999·European Journal of Pharmacology·J C StocletA L Kleschyov
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Oct 26, 2002·Free Radical Biology & Medicine·Alberto BoverisAna Navarro
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Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Mohammed S H El-AwadyMalcolm L Watson
Jul 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M AldasoroS Lluch
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A L KleschyovJ C Stoclet

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