An LC-ESI-MS/MS method for residues of fluoroquinolones, sulfonamides, tetracyclines and trimethoprim in feedingstuffs: validation and surveillance

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Louise JankTânia Mara Pizzolato

Abstract

An increasing concern about food safety has been observed over the years. The presence of drugs residues in food is one of the major subjects of research in food safety. Feedingstuffs can be responsible for carryover into the food chain of residues of several drugs. This paper describes the development, validation and application of a fast and simple method for analysis of 24 antibiotic residues in feedingstuffs for cattle, pigs and poultry. Analytes include compounds from different antimicrobials classes, such as sulfonamides (sulfadiazine, sulfamethazine, sulfamethoxazole, sulfaquinoxaline, sulfachlorpyridazine, sulfadoxine, sulfadimethoxine, sulfizoxazole, sulfamerazine and sulfathiazole), fluoroquinolones (ciprofloxacin, enrofloxacin, norfloxacin, danofloxacin, difloxacin, sarafloxacin, flumequine, nalidixic acid and oxolinic acid), tetracyclines (tetracycline, doxycycline, oxytetracycline and chlortetracycline) and trimethoprim. Samples were extracted with methanol:water (70:30) 0.1% formic acid, followed by clean-up steps using centrifugation, low-temperature purification (LTP) and ultracentrifugation. Instrumental analysis was performed using liquid chromatography coupled to tandem mass spectrometry. Chromatographic sepa...Continue Reading

References

Mar 17, 2009·Analytica Chimica Acta·Angelo de Q MauricioMarcelo B Alvarenga
Apr 29, 2009·Journal of Environmental Quality·Joanne C Chee-SanfordRustam I Aminov
Jan 11, 2011·Toxicology and Applied Pharmacology·J L C M DorneJ Fink-Gremmels
Oct 2, 2013·Analytical and Bioanalytical Chemistry·Monique E Bienenmann-PloumMichel W F Nielen
Mar 19, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·María Luz Gómez-PérezAntonia Garrido Frenich
Jun 30, 2015·Future Microbiology·Victoire de Lastours, Bruno Fantin
Aug 8, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Robin S WeghLeen A Van Ginkel
Dec 9, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ewelina PatyraKrzysztof Kwiatek

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