An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats.

Psychopharmacology
Takao YoshimizuShigeyuki Chaki

Abstract

Abnormalities of glutamatergic neurotransmission have been reportedly observed in psychiatric disorders. Previously, we demonstrated that (1R, 2R, 3R, 5R, 6R)-2-Amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039) is a selective antagonist for group II metabotropic glutamate receptors (mGluR2/3), and that it exerted antidepressant effects in some animal behavioral tests. In the present study, we provide additional evidence that MGS0039 exhibits antidepressant and anxiolytic effects in experimental rodent models, which are predictive of clinical efficacy. The learned helplessness (LH) paradigm, which is a common model used to examine the depressive state, was used to assess antidepressant effects of MGS0039. Moreover, anxiolytic effects of MGS0039 were investigated in the conditioned fear stress (CFS) model, which represents emotional abnormality, including anxiety. Intraperitoneal administration of MGS0039 (10 mg/kg) to rats for 7 days elicited a significant reduction in escape failures in the LH paradigm. In addition, rats treated with MGS0039 (2 mg/kg) showed significantly attenuated freezing behavior in a CFS model, indicating the anxiolytic-like potential of MGS0039. These results sug...Continue Reading

References

Feb 1, 1975·Journal of Comparative and Physiological Psychology·M E Seligman, G Beagley
Oct 1, 1992·Pharmacology, Biochemistry, and Behavior·F PettyL Wilson
Jan 1, 1990·Psychopharmacology·P MartinA J Puech
Apr 1, 1988·Behavioral Neuroscience·M S Fanselow, F J Helmstetter
Aug 1, 1982·Behavioral and Neural Biology·A D Sherman, F Petty
Apr 1, 1983·Pharmacology, Biochemistry, and Behavior·F Petty, A D Sherman
Mar 1, 1982·Pharmacology, Biochemistry, and Behavior·A D ShermanF Petty
Apr 1, 1996·Pharmacology, Biochemistry, and Behavior·T InoueT Koyama
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·P J Conn, J P Pin
Sep 9, 1999·European Journal of Pharmacology·S HashimotoT Koyama
Sep 15, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·D R RosenbergG J Moore
Dec 26, 2001·Journal of Neurochemistry·S MangiavacchiC Gambarana
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·David L Walker, Michael Davis
Feb 19, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert E McCullumsmith, James H Meador-Woodruff
Jun 5, 2003·The American Journal of Psychiatry·Sarah M ClintonJames H Meador-Woodruff
Jul 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica E Malberg, Ronald S Duman
Sep 18, 2003·Stress : the International Journal on the Biology of Stress·Darryle D SchoeppWilliam Z Potter
Sep 1, 2004·European Journal of Pharmacology·Takeshi InoueTsukasa Koyama
Mar 23, 2005·Neuroscience Letters·Naoya KawashimaAtsuro Nakazato
Sep 30, 2005·International Clinical Psychopharmacology·Veerle Bergink, Herman G M Westenberg

❮ Previous
Next ❯

Citations

Aug 13, 2010·Psychopharmacology·Agnieszka Pałucha-PoniewieraAndrzej Pilc
Aug 15, 2013·Cell and Tissue Research·Vincenzo MicaleAlexandra Sulcova
Feb 2, 2013·CNS Spectrums·Mario Catena-Dell'OssoDonatella Marazziti
Sep 9, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaohua LiRichard C Shelton
Nov 30, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maria SmiałowskaBarbara Zieba
Feb 1, 2007·Pharmacogenetics and Genomics·Chi-Un PaeIn-Ho Paik
May 28, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Rodrigo Machado-VieiraCarlos A Zarate
Sep 15, 2010·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Michihiko IijimaShigeyuki Chaki
Sep 10, 2010·Harvard Review of Psychiatry·Carlos ZarateGiacomo Salvadore
Aug 21, 2013·Progress in Neurobiology·C Patte-MensahA G Mensah-Nyagan
Aug 28, 2013·Progress in Neurobiology·T BäckströmG van Wingen
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Carla NascaFerdinando Nicoletti
Jul 12, 2007·Psychopharmacology·Agnieszka PaluchaAndrzej Pilc
Apr 21, 2010·Neurochemical Research·Roberto Farina AlmeidaMarcelo Ganzella
Jul 6, 2007·Expert Review of Neurotherapeutics·Vidita A VaidyaShanker Jha
Sep 24, 2015·Pharmaceuticals·Shigeyuki Chaki, Kenichi Fukumoto
Oct 1, 2007·Expert Opinion on Drug Discovery·Chad E Beyer, Zoë A Hughes
Nov 17, 2006·Expert Opinion on Investigational Drugs·Agnieszka Palucha
Feb 29, 2016·Pharmacological Reports : PR·Karolina PytkaBarbara Filipek
Mar 5, 2013·Biological Psychiatry·Andrzej PilcPhil Skolnick
Oct 6, 2011·Pharmacology, Biochemistry, and Behavior·Rodrigo Machado-VieiraCarlos A Zarate
May 17, 2011·Pharmacology, Biochemistry, and Behavior·Carlos Riaza Bermudo-SorianoEnrique Baca-Garcia
May 4, 2011·Pharmacology, Biochemistry, and Behavior·Kenichi TokitaKenji Hashimoto
Nov 3, 2010·Neuropharmacology·F NicolettiJ P Pin
Oct 19, 2010·Journal of Psychiatric Research·Katharina DomschkeBernhard T Baune
Dec 1, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anteneh M FeyissaBeata Karolewicz
Oct 16, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Miguel Molina-HernándezM Teresa Jaramillo-Jaimes
Jan 1, 2008·Biochemical Pharmacology·Andrzej PilcJeffrey M Witkin
Jun 22, 2007·Pharmacology & Therapeutics·Agnieszka Palucha, Andrzej Pilc
Aug 16, 2008·The Mount Sinai Journal of Medicine, New York·Carlos A Zarate, Husseini K Manji
Apr 27, 2011·Journal of Neurochemistry·Wei-Li ZhuLin Lu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.