An MRI study of spatial probability brain map differences between first-episode schizophrenia and normal controls

NeuroImage
H ParkRobert W McCarley

Abstract

We created a spatial probability atlas of schizophrenia to provide information about the neuroanatomic variability of brain regions of patients with the disorder. Probability maps of 16 regions of interest (ROIs) were constructed by taking manually parcellated ROIs from subjects' magnetic resonance images (MRIs) and linearly transforming them into Talairach space using the Montreal Neurological Institute (MNI) template. ROIs included temporal, parietal, and prefrontal cortex subregions, with a principal focus on temporal lobe structures. Subject Ns ranged from 11 to 28 for the different ROIs. Our global measure of the spatial distribution of the transformed ROI was the sum of voxels with 50% overlap among subjects. The superior temporal gyrus (STG) and fusiform gyrus (FG) had lower values for schizophrenic subjects than for normal controls, suggestive of greater spatial variability for these ROIs in schizophrenic subjects. For the computation of statistical significance of group differences in portions of the ROI, we used voxel-wise comparisons and Fisher's exact test. First-episode schizophrenic patients compared with controls showed lower probability (P < 0.05) at dorso-posterior areas of planum temporale and Heschl's gyrus, ...Continue Reading

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Citations

Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel Paul Eisenberg, Karen Faith Berman
Nov 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joshua L RoffmanDara S Manoach
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Apr 7, 2010·Schizophrenia Research·Chandlee C DickeyRobert W McCarley
Mar 30, 2010·Journal of Neuroscience Methods·Chih-Mao HuangHo-Ling Liu
Jul 31, 2008·Journal of Magnetic Resonance Imaging : JMRI·Ihssan A Abdul-Kareem, Vanessa Sluming
Mar 5, 2010·Early Intervention in Psychiatry·Lisa BuchyMartin Lepage
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Nov 30, 2006·Human Brain Mapping·Hae-Jeong ParkJong Doo Lee

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