PMID: 18716175Aug 22, 2008Paper

An (n-3) polyunsaturated fatty acid-deficient diet disturbs daily locomotor activity, melatonin rhythm, and striatal dopamine in Syrian hamsters

The Journal of Nutrition
Monique LavialleI Denis

Abstract

Several studies suggest that (n-3) PUFA may play a role in the regulation of cognitive functions, locomotor and exploratory activity, and affective disorders. Additionally, (n-3) PUFA affect pineal function, which is implicated in the sleep-wake rhythm. However, no studies to our knowledge have explored the role of PUFA on the circadian system. We investigated the effect of an (n-3) PUFA-deficient diet on locomotor and pineal melatonin rhythms in Syrian hamsters used as model species in circadian rhythm research. To assess the possible relationship between voluntary wheel running activity and dopaminergic neurotransmission, we also measured endogenous monoamine concentrations in the striatum. Two-month-old male hamsters, fed either an (n-3) PUFA-deficient or an (n-3) PUFA-adequate diet, were housed individually in cages equipped with run wheels. At 3 mo, cerebral structures were extracted for biochemical and cellular analysis. In (n-3) PUFA-deficient hamsters, the induced changes in the pineal PUFA membrane phospholipid composition were associated with a reduction in the nocturnal peak level of melatonin that was 52% lower than in control hamsters (P < 0.001). The (n-3) PUFA-deficient hamsters also had higher diurnal (P < 0.01)...Continue Reading

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Citations

Oct 22, 2008·The Journal of Physiology·Jorge MendozaEtienne Challet
Dec 15, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J J Puder, S Munsch
Apr 9, 2013·Attention Deficit and Hyperactivity Disorders·G IrmischR Wandschneider
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Jun 5, 2021·Critical Reviews in Food Science and Nutrition·Junjie LinChun Cui
Jul 26, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Géraldine MathieuSylvie Vancassel

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