An objective approach to dry eye disease severity

Investigative Ophthalmology & Visual Science
Benjamin D SullivanMichael A Lemp

Abstract

A prospective, multisite clinical study (10 sites in the European Union and the United States) evaluated the clinical utility of commonly used tests and tear osmolarity for assessing dry eye disease severity. Three hundred fourteen consecutive subjects between the ages of 18 and 82 years were recruited from the general patient population, 299 of which qualified with complete datasets. Osmolarity testing, Schirmer test without anesthesia, tear film breakup time (TBUT), corneal staining, meibomian dysfunction assessment, and conjunctival staining were performed bilaterally. A symptom questionnaire, the Ocular Surface Disease Index (OSDI), was also administered to each patient. Distributions of clinical signs and symptoms against a continuous composite severity index were evaluated. Osmolarity was found to have the highest correlation coefficient to disease severity (r(2) = 0.55), followed by conjunctival staining (r(2) = 0.47), corneal staining (r(2) = 0.43), OSDI (r(2) = 0.41), meibomian score (r(2) = 0.37), TBUT (r(2) = 0.30), and Schirmer result (r(2) = 0.17). A comparison of standard threshold-based classification with the composite severity index revealed significant overlap between the disease severities of prospectively de...Continue Reading

Citations

Jul 16, 2013·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Nina TranMeng C Lin
Sep 10, 2013·Experimental Eye Research·Isabelle Jalbert
Feb 1, 2013·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Nathan EfronJinzhong Zhang
Mar 30, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Minako KaidoKazuo Tsubota
Aug 8, 2012·Eye & Contact Lens·Ming LiJianhua Wang
Jun 20, 2012·Cornea·Antoine LabbéChristophe Baudouin
Aug 21, 2012·Cornea·Gemma JulioDolores Merindano
Feb 15, 2013·Cornea·Vatinee Y BunyaGiacomina Massaro-Giordano
Aug 14, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Daniel G FullerJeung Kim
Mar 20, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Giancarlo Montani
Mar 23, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Moneisha GokhaleIsabelle Jalbert
Aug 6, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Chi-Chin SunPei-Hsuan Wu
Mar 21, 2013·Investigative Ophthalmology & Visual Science·Shivaram SelvamSamuel C Yiu
Mar 28, 2013·Investigative Ophthalmology & Visual Science·Carolyn BegleyPing Situ
Jun 15, 2013·Investigative Ophthalmology & Visual Science·P Ewen King-SmithKelly K Nichols
Aug 15, 2013·Investigative Ophthalmology & Visual Science·Craig SeeAnat Galor
Jan 15, 2011·Medicine and Science in Sports and Exercise·Matthew B FortesNeil P Walsh
Nov 2, 2011·PloS One·Sin Man LamMarkus R Wenk
Apr 4, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yureeda QaziPedram Hamrah
Mar 15, 2014·The British Journal of Ophthalmology·Christophe BaudouinUNKNOWN ODISSEY European Consensus Group members
Dec 24, 2013·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Etty Bitton, Walter Wittich
Jul 12, 2014·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Paramdeep S BilkhuShehzad A Naroo
Apr 30, 2014·Expert Opinion on Pharmacotherapy·Basilio ColligrisJesus Pintor
Nov 5, 2011·Current Eye Research·Eszter FodorJános Németh
Jul 26, 2011·Current Eye Research·Canan Asli UtineFerda Çiftçi
Aug 9, 2011·Current Eye Research·Alvin Eisner, Shiuh-Wen Luoh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.