An obligatory caravanserai stop on the silk road to neural induction: inhibition of BMP/GDF signaling

Seminars in Cell & Developmental Biology
Alin Vonica, Ali H Brivanlou

Abstract

Work in Xenopus laevis produced the first molecular explanation for neural specification, the default model, where inactivation of the BMP pathway in ectodermal cells changes fates from epidermal to neural. This review covers the present status of our understanding of neural specification, with emphasis on Xenopus, but including relevant facts in other model systems. While recent experiments have increased the complexity of the molecular picture, they have also provided additional support for the default model and the central position of the BMP pathway. We conclude that synergy between accumulated knowledge and technical progress will maintain Xenopus at the forefront of research in neural development.

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Citations

Dec 19, 2013·ELife·Margarida Sancho, Tristan A Rodríguez
Mar 6, 2012·Differentiation; Research in Biological Diversity·Chen LiuAmy K Sater
Apr 18, 2009·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yuka NakajimaTai Kubo
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Jun 8, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shaonli Das, Chenbei Chang
Feb 25, 2015·Development, Growth & Differentiation·Ke TangNaihe Jing
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Jul 15, 2016·Cold Spring Harbor Perspectives in Biology·Chenbei Chang
Mar 23, 2017·ELife·J Terrig ThomasMalcolm Moos
Aug 19, 2007·Development·Aida Di-GregorioTristan A Rodriguez

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