An observational retrospective evaluation of 79 young men with long-term adverse effects after use of finasteride against androgenetic alopecia

Andrology
G ChiriacòCarlo Trombetta

Abstract

Concern regarding adverse effects of finasteride is increasing. We aimed to determine the type and frequency of symptoms in men having long-term sexual and non-sexual side effects after finasteride treatment (a condition recently called post-finasteride syndrome, PFS) against androgenetic alopecia (AGA). Subjects were recruited at the Urology Unit of the Trieste University-Hospital, and from a dedicated website. Out of 79 participants, 34% were white Italians, mean age was 33.4 ± 7.60 years, mean duration of finasteride use was 27.3 ± 33.21 months; mean time from finasteride discontinuation was 44.1 ± 34.20 months. Symptoms were investigated by an ad hoc 100 questions' questionnaire, and by validated Arizona Sexual Experience Scale (ASEX) and Aging Male Symptom Scale (AMS) questionnaires. By ASEX questionnaire, 40.5% of participants declared getting and keeping erection very difficult, and 3.8% never achieved; reaching orgasm was declared very difficult by 16.5%, and never achieved by 2.5%. By the ad hoc questionnaire, the most frequent sexual symptoms referred were loss of penis sensitivity (87.3%), decreased ejaculatory force (82.3%), and low penile temperature (78.5%). The most frequent non-sexual symptoms were reduced feeli...Continue Reading

References

Nov 1, 1975·Southern Medical Journal·O T Norwood
Oct 22, 1992·The New England Journal of Medicine·G J GormleyJ S Tenover
Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·G J GormleyE A Stein
Feb 29, 2000·Journal of Sex & Marital Therapy·C A McGahueyR Manber
Apr 3, 2003·Urology·Franklin C LoweUNKNOWN Finasteride Study Group
May 16, 2003·Health and Quality of Life Outcomes·Lothar A J HeinemannChristelle Giroudet
Apr 1, 2006·Health and Quality of Life Outcomes·Lothar A HeinemannDiana Stoehr
Nov 3, 2009·Steroids·Saurabh AggarwalManoj Kumar
Oct 20, 2010·Archives of Dermatology·José Manuel MellaGordon Guyatt
Mar 23, 2011·The Journal of Sexual Medicine·Michael S Irwig, Swapna Kolukula
Mar 2, 2012·The Journal of Sexual Medicine·Min-Guang ZhangZhou-Jun Shen
Mar 12, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Frank Z StanczykMalcolm C Pike
Jul 16, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Abdulmaged M Traish, Abraham Morgentaler
Jun 15, 2014·American Journal of Men's Health·Christine Anne GanzerFarin Iqbal
Apr 15, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Michael S Irwig

❮ Previous
Next ❯

Citations

Mar 22, 2019·The Journal of Dermatological Treatment·Ion G MotofeiSimona R Georgescu
Oct 16, 2018·Expert Opinion on Drug Safety·Hind M AlmohannaAntonella Tosti
Jun 18, 2018·Current Urology Reports·Mohammed A Said, Akanksha Mehta
Sep 14, 2018·The World Journal of Men's Health·Yu Seob ShinJong Kwan Park
Apr 3, 2020·Human Psychopharmacology·Hesham Y Elnazer, David S Baldwin
Feb 25, 2017·Der Urologe. Ausg. A·J WolfesbergerS Madersbacher
Sep 21, 2020·Journal of Endocrinological Investigation·F BorgoR C Melcangi
Sep 26, 2017·The Journal of Clinical Endocrinology and Metabolism·Wylie C HembreeGuy G T'Sjoen
Apr 21, 2018·Endocrine·Silvia GiattiRoberto Cosimo Melcangi
Dec 29, 2020·Journal of Genetic Counseling·Alexander M von Vaupel-Klein, Reubs J Walsh
Feb 9, 2020·Fertility and Sterility·Abdulmaged M Traish
Apr 6, 2021·Journal of Clinical Psychopharmacology·Maurizio PompiliRoss J Baldessarini
Jul 13, 2021·The Journal of Sexual Medicine·Skyler HowellMohit Khera
Jan 15, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Michael S Irwig

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.