An observational study of assisted reproductive technology outcomes in new European Union member states: an overview of protocols used for ovarian stimulation

Current Medical Research and Opinion
Veljko VlaisavljevićGints Treijs

Abstract

The development of new fertility treatment options has facilitated individualized assisted reproductive technology (ART) protocols to improve outcomes. Manufacturing improvements to recombinant human follitropin alfa have allowed precise dosing based on mass (filled-by-mass; FbM) rather than bioactivity (filled-by-bioassay; FbIU). Continued monitoring and reporting of follitropin alfa treatment outcomes in routine clinical practice is essential. To provide an overview of the frequency of different controlled ovarian-stimulation protocols used in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles in new European Union member states, and to provide post-registration efficacy and safety data on follitropin alfa. A 2-year, prospective, observational, multicentre, Phase IV study conducted at ART clinics in the Czech Republic, Estonia, Latvia, Lithuania, Poland, Slovakia and Slovenia. Women aged 18-47 years undergoing ovarian stimulation with follitropin alfa for conventional IVF or ICSI were eligible for inclusion. The main treatment outcome was cumulative clinical pregnancy rate. Data were analysed descriptively. Clinical pregnancy outcomes were available for 4055 of 4085 (99.3%) patients. In total, 189...Continue Reading

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Citations

Oct 9, 2015·Women's Health·Bulent Haydardedeoglu, Hulusi Bulent Zeyneloglu

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