An observational study of febrile seizures: the importance of viral infection and immunization

BMC Pediatrics
Joshua R FrancisChristopher C Blyth

Abstract

Febrile seizures are common in young children. Annual peaks in incidence mirror increased respiratory virus activity during winter. Limited virological data are available using modern diagnostic techniques for children with febrile seizures. We aimed to determine the frequency of detection of specific viral pathogens in children with febrile seizures, to describe risk factors including recent vaccination and clinical features associated with specific etiologies. An observational study was performed. Children aged 6 months to 5 years presenting to the Emergency Department of a tertiary children's hospital in Western Australia with febrile seizures were enrolled between March 2012 and October 2013. Demographic, clinical data and vaccination history were collected, and virological testing was performed on per-nasal and per-rectal samples. One hundred fifty one patients (72 female; median age 1.7y; range 6 m-4y9m) were enrolled. Virological testing was completed for 143/151 (95%). At least one virus was detected in 102/143 patients (71%). The most commonly identified were rhinoviruses (31/143, 22%), adenovirus (30/151, 21%), enteroviruses, (28/143, 20%), influenza (19/143, 13%) and HHV6 (17/143, 12%). More than one virus was found ...Continue Reading

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Citations

Sep 10, 2019·Future Microbiology·Francisco ÁlvarezFederico Martinón-Torres
Jul 15, 2020·Journal of Child Neurology·Alison Christy
Sep 21, 2018·Human Vaccines & Immunotherapeutics·Kursat Bora CarmanEner Cagri Dinleyici
Oct 21, 2020·BMC Infectious Diseases·Siri Helene HaugeSiri Eldevik Håberg
Dec 8, 2020·Seizure : the Journal of the British Epilepsy Association·Maria HautalaTerhi Tapiainen
Nov 13, 2020·Clinical Microbiology Reviews·Anthony L KomaroffSteven Jacobson
Nov 30, 2020·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Ting Gee Annie ChiuRichard Shek-Kwan Chang
Aug 8, 2021·International Journal of Molecular Sciences·Tatyana Y PostnikovaAleksey V Zaitsev

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Methods Mentioned

BETA
PCR
PCRs

Software Mentioned

Excel
GraphPad Prism
GraphPad

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