An observational study of Yasmin in the management of women with polycystic ovary syndrome

The Journal of Family Planning and Reproductive Health Care
Manisha Palep-SinghAdam Balen

Abstract

Polycystic ovary syndrome (PCOS) is the commonest endocrine disturbance affecting women in the reproductive age group and encompasses signs of hyperandrogenism, menstrual cycle disturbances and obesity. Some of the symptoms of PCOS may be ameliorated by the combined oral contraceptive pill (COCP). A pilot observational study was carried out in a university teaching hospital setting to determine whether the clinical and biochemical features of PCOS are ameliorated by a new COCP, Yasmin, which contains a new progestogen, drosperinone. Treatment with Yasmin was given for 6 months to 17 patients. Thirteen patients (76%) completed 6 months of therapy. Good cycle control was achieved in all patients. Percentage body fat increased, with no overall change in body mass index. Fasting insulin and triglyceride concentrations rose significantly. Serum total testosterone concentrations fell with a concomitant rise in sex hormone binding globulin levels. Hirsutism scores did not change significantly in the 12 women who were clinically hirsute. There was, however, a significant improvement in the acne scores. Four of the 17 patients dropped out of the trial between Cycles 3 and 5 due to side effects. Yasmin provides good cycle control for wom...Continue Reading

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Citations

Nov 5, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Salvatore CarusoAntonio Cianci
May 1, 2007·Women's Health·Ephia Yasmin, Adam H Balen
Apr 25, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·R K Bhathena
Apr 25, 2007·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·B Pehlivanov, M Mitkov
Nov 29, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sudhindra M BhattacharyaLipika DasMukhopadhyay
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Dec 2, 2014·Journal of the American Academy of Dermatology·Elizabeth BuzneyRachel V Reynolds
Jun 15, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Paolo Moghetti, Vincenzo Toscano
Dec 9, 2017·Reproductive Biology and Endocrinology : RB&E·Sebastião Freitas de Medeiros
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Feb 17, 2007·Clinical Obstetrics and Gynecology·Suma Dronavalli, David A Ehrmann
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