PMID: 3762223Aug 1, 1986Paper

An on-line spike form discriminator for extracellular recordings based on an analog correlation technique

Journal of Neuroscience Methods
F WörgötterR Eckmiller

Abstract

The discrimination of single unit activity in extracellular recordings presents a serious problem when the signal-to-noise ratio is low or when the amplitudes of interspersed spikes are similar. By exploiting spike form, the system described here performs discrimination using on-line hardware template matching. Using analog delay lines, the combined deviation of 8 input signal values from 8 stored template values is calculated simultaneously. The 8 template values are selected by adjusting 8 cursors to the desired spike trace on a CRT; the spike form discriminator (SPIFODIS) then generates a deviation function which steeply drops to zero whenever form similarity occurs, allowing for easy triggering. The performance of SPIFODIS was compared quantitatively with that of a conventional amplitude trigger in two cases: when detecting a single unit with varied signal-to-noise ratios and when separating double units of equal amplitude. At signal-to-noise ratios between 2 and 1 the error rate for SPIFODIS was only 15-50% of that of an amplitude trigger. In double-unit recordings showing only form differences, spikes are discriminated with very low error rate, while an amplitude trigger fails completely.

References

Oct 1, 1975·Electroencephalography and Clinical Neurophysiology·R Eckmiller, J Petsch
Sep 1, 1977·IEEE Transactions on Bio-medical Engineering·M J Bak, E M Schmidt
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Feb 1, 1965·Electroencephalography and Clinical Neurophysiology·W SIMON

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Citations

May 1, 1993·Medical & Biological Engineering & Computing·E V GoodallC M Lybbert
Jun 1, 1988·Journal of Neuroscience Methods·B B EdinL O Bäckström
Feb 1, 1990·Journal of Neuroscience Methods·C Forster, H O Handwerker
Mar 1, 1992·Journal of Neuroscience Methods·H Bergman, M R DeLong
Apr 1, 1995·Journal of Neuroscience Methods·R Gädicke, K Albus
Nov 20, 1998·Journal of Neuroscience Methods·R K Snider, A B Bonds
Jun 15, 2011·Cerebral Cortex·Konstantin TziridisPeter Thier
Jan 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elias B Issa, Xiaoqin Wang
Mar 15, 2013·Journal of Neurophysiology·Elias B Issa, Xiaoqin Wang
Aug 3, 2007·Journal of Neuroscience Methods·Sunghan Kim, James McNames
May 5, 2007·Journal of Neuroscience Methods·Mati JoshuaHagai Bergman
Mar 16, 2007·IEEE Transactions on Bio-medical Engineering·Lakshminarayan Srinivasan, Emery N Brown
Mar 1, 1992·IEEE Transactions on Bio-medical Engineering·E V Goodall, K W Horch
Jul 10, 2012·IEEE Transactions on Bio-medical Engineering·Vahid ShalchyanDario Farina
Jun 24, 2017·IEEE Transactions on Bio-medical Engineering·Sasan YazdaniJean-Marc Vesin
May 13, 2011·Journal of Neurophysiology·Sidney R LehkyKeiji Tanaka
Aug 1, 2014·Journal of Neurophysiology·Nazli Emadi, Hossein Esteky
May 7, 2020·Journal of Neurophysiology·Akshay MarkandayPeter Thier

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