An onion variety has natural antithrombotic effect as assessed by thrombosis/thrombolysis models in rodents

Thrombosis Research
Kaori YamadaJunichiro Yamamoto

Abstract

Prevention of arterial thrombotic diseases has a high priority in developed countries. As inappropriate diet has been shown to be an important risk factor for thrombotic events, regular antithrombotic diet may offer a convenient and effective way of prevention. The aim of the present study was to test onion extracts for antithrombotic effect and to identify the effective varieties in Allium cepa. A shear-induced platelet function test (haemostatometry) was used to screen for antithrombotic potential. Onion extracts showing significant antithrombotic activity in vitro were further assessed in vivo by using a laser-induced thrombosis test in mice. An onion variety, Toyohira, showed significant antithrombotic activity both in vitro and in vivo. Toyohira showed thrombolytic activity in addition to the antiplatelet effect. Superkitamomiji, 2935A, and K83211 showed only thrombolytic activity. Quercetin, the richest flavonoid in onion, was measured, but no correlation was found between quercetin content and antithrombotic activity. It is concluded that onion A. cepa can be classified into varieties with or without antithrombotic and thrombolytic effects. This should be taken into account in future population studies on the antithrombo...Continue Reading

References

Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G TamuraB N Ames
Apr 12, 1995·JAMA : the Journal of the American Medical Association·M W GillmanP A Wolf
Jul 1, 1994·Bioscience, Biotechnology, and Biochemistry·N TeraharaT Honda
Feb 24, 1996·BMJ : British Medical Journal·P KnektJ Maatela
Dec 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J V Formica, W Regelson
May 13, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M AliT Mustafa
Jan 5, 2002·The New England Journal of Medicine·B G BrownJ J Albers
Dec 4, 2003·The British Journal of Nutrition·J YamamotoT Yoshida

❮ Previous
Next ❯

Citations

Dec 31, 2010·The Journal of Nutritional Biochemistry·Keunyoung KimJin-Ho Chung
Dec 3, 2015·Plant Foods for Human Nutrition·Ana Clara SabbioneAdriana A Scilingo
Mar 26, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seung-Min LeeMin-Jeong Shin
Jul 20, 2016·Drug Discoveries & Therapeutics·Junichiro YamamotoYoshio Okada
Jul 3, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Sweta R ChourasiaHatim F Daginawala
Jul 25, 2018·Critical Reviews in Food Science and Nutrition·Joaheer D TeshikaMahomoodally M Fawzi
Nov 13, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Junichiro YamamotoJohn C Giddings
Sep 22, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Aki NaemuraJunichiro Yamamoto
Nov 28, 2006·Platelets·Junichiro YamamotoAkio Koyama
Jan 19, 2007·Pathophysiology of Haemostasis and Thrombosis·Aki NaemuraJunichiro Yamamoto
Feb 12, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Constanza Torres-UrrutiaIván Palomo
May 8, 2020·Circulation Research·Francesco VioliRoberto Carnevale
Jan 20, 2015·Journal of Agricultural and Food Chemistry·Leticia Mora, Maria Hayes
Nov 14, 2007·Journal of Agricultural and Food Chemistry·Rune SlimestadIngunn Molund Vågen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

The British Journal of Nutrition
J YamamotoT Yoshida
Pathophysiology of Haemostasis and Thrombosis
Aki NaemuraJunichiro Yamamoto
Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Aki NaemuraJunichiro Yamamoto
© 2021 Meta ULC. All rights reserved