Abstract
Prevention of arterial thrombotic diseases has a high priority in developed countries. As inappropriate diet has been shown to be an important risk factor for thrombotic events, regular antithrombotic diet may offer a convenient and effective way of prevention. The aim of the present study was to test onion extracts for antithrombotic effect and to identify the effective varieties in Allium cepa. A shear-induced platelet function test (haemostatometry) was used to screen for antithrombotic potential. Onion extracts showing significant antithrombotic activity in vitro were further assessed in vivo by using a laser-induced thrombosis test in mice. An onion variety, Toyohira, showed significant antithrombotic activity both in vitro and in vivo. Toyohira showed thrombolytic activity in addition to the antiplatelet effect. Superkitamomiji, 2935A, and K83211 showed only thrombolytic activity. Quercetin, the richest flavonoid in onion, was measured, but no correlation was found between quercetin content and antithrombotic activity. It is concluded that onion A. cepa can be classified into varieties with or without antithrombotic and thrombolytic effects. This should be taken into account in future population studies on the antithrombo...Continue Reading
References
Mar 1, 1992·Circulation·C P RatnatungaI B Kovacs
Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G TamuraB N Ames
Apr 12, 1995·JAMA : the Journal of the American Medical Association·M W GillmanP A Wolf
Jul 1, 1994·Bioscience, Biotechnology, and Biochemistry·N TeraharaT Honda
Feb 24, 1996·BMJ : British Medical Journal·P KnektJ Maatela
Dec 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J V Formica, W Regelson
May 13, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M AliT Mustafa
Jan 5, 2002·The New England Journal of Medicine·B G BrownJ J Albers
Aug 23, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Y IjiriJ Yamamoto
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·G P HubbardJ M Gibbins
Dec 4, 2003·The British Journal of Nutrition·J YamamotoT Yoshida
Citations
Dec 31, 2010·The Journal of Nutritional Biochemistry·Keunyoung KimJin-Ho Chung
Dec 3, 2015·Plant Foods for Human Nutrition·Ana Clara SabbioneAdriana A Scilingo
Mar 26, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seung-Min LeeMin-Jeong Shin
Jul 20, 2016·Drug Discoveries & Therapeutics·Junichiro YamamotoYoshio Okada
Apr 2, 2008·Thrombosis Research·Aki NaemuraJunichiro Yamamoto
Jul 3, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Sweta R ChourasiaHatim F Daginawala
Aug 11, 2017·Nutrients·Guo-Yi TangHua-Bin Li
Jul 25, 2018·Critical Reviews in Food Science and Nutrition·Joaheer D TeshikaMahomoodally M Fawzi
Nov 13, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Junichiro YamamotoJohn C Giddings
Sep 22, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Aki NaemuraJunichiro Yamamoto
Nov 28, 2006·Platelets·Junichiro YamamotoAkio Koyama
Jan 19, 2007·Pathophysiology of Haemostasis and Thrombosis·Aki NaemuraJunichiro Yamamoto
Feb 12, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Constanza Torres-UrrutiaIván Palomo
May 8, 2020·Circulation Research·Francesco VioliRoberto Carnevale
Feb 14, 2019·Advances in Nutrition·Beata Olas
Apr 24, 2018·Future Science OA·Junichiro YamamotoKjell S Sakariassen
Jan 14, 2021·Future Science OA·Masahiro IwasakiJunichiro Yamamoto
Jan 27, 2010·Journal of Agricultural and Food Chemistry·Marie E OlssonIngunn M Vågen
Jan 20, 2011·Journal of Agricultural and Food Chemistry·Jihyun Lee, Alyson E Mitchell
Jan 20, 2015·Journal of Agricultural and Food Chemistry·Leticia Mora, Maria Hayes
Nov 14, 2007·Journal of Agricultural and Food Chemistry·Rune SlimestadIngunn Molund Vågen