PMID: 6986093Jan 1, 1980Paper

An open clinical trial of L-dopa and carbidopa in adults with minimal brain dysfunction

The American Journal of Psychiatry
F W ReimherrP H Wender

Abstract

MBD has long been considered a childhood disorders. Recent research suggests that in some it persists into adult life and that at least one form is a consequence of reduced activity of dopaminergic systems in the brain. To test this hypothesis, three adults with "presumptive" MBD were given L-dopa plus carbidopa. Although overall this combination was less effective than stimulant medication, all the patients showed an initial response, and in one patient L-dopa seemed to potentiate the effect of methylphenidate. The authors point out that various dopamine agonists have different effects and that the possible potentiation effect is consistent with a dopaminergic hypothesis.

Citations

Feb 1, 1982·Psychiatry Research·D WoodP H Wender
Feb 23, 2002·Drug Development and Industrial Pharmacy·Jun-Ichi SudoKozo Takayama
Jan 1, 1982·Journal of the American Academy of Child Psychiatry·D H LangerW E Bunney
May 1, 1987·Journal of the American Academy of Child and Adolescent Psychiatry·M S SokolA M Kriechman
Sep 1, 1985·The Australian and New Zealand Journal of Psychiatry·J Cawte
Jan 15, 2010·Journal of Attention Disorders·Paul H WenderDavid A Tomb
Jul 1, 1988·Brain Injury : [BI]·S LalJ C Grip

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