An open cohort study of bone metastasis incidence following surgery in breast cancer patients.

BMC Cancer
Mitsuru KoizumiTakuji Iwase

Abstract

To help design clinical trials of adjuvant bisphosphonate therapy for breast cancer, the temporal incidence of bone metastasis was investigated in a cohort of patients. We have tried to draw the criteria to use adjuvant bisphosphonate. Consecutive breast cancer patients undergoing surgery between 1988 and 1998 (5459 patients) were followed up regarding bone metastasis until December 2006. Patients' characteristics at the time of surgery were analyzed by Cox's method, with bone metastasis as events. Patient groups were assigned according to Cox's analysis, and were judged either to require the adjuvant bisphosphonate or not, using the tentative criteria: high risk (>3% person-year), medium risk (1-3%), and low risk (<1%). Bone metastasis incidence was constant between 1.0 and 2.8% per person-year more than 10 years. Non-invasive cancer was associated with a very low incidence of bone metastasis (1/436). Multivariate Cox's analysis indicated important factors for bone metastasis were tumor grade (T), nodal grade (pN), and histology. Because T and pN were important factors for bone metastasis prediction, subgroups were made by pTNM stage. Patients at stages IIIA, IIIB and IV had an incidence of >3% per person-year, patients with s...Continue Reading

References

Mar 1, 1975·The British Journal of Surgery·D L CitrinL H Blumgart
Mar 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A PedrazziniA Goldhirsch
Jan 1, 1984·Breast Cancer Research and Treatment·L WickerhamW Cronin
Aug 1, 1984·European Journal of Cancer & Clinical Oncology·H S ThomsenN Rossing
Feb 1, 1981·Cancer·N A SamaanR Martin
Sep 1, 1981·British Journal of Cancer·F C CampbellJ L Haybittle
Jan 1, 1994·Breast Cancer Research and Treatment·J F RobertsonR W Blamey
May 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Jun 9, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Castiglione-GertschC M Rudenstam
Aug 6, 1998·The New England Journal of Medicine·I J DielG Bastert
Mar 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B E HillnerD G Pfister
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T SaartoI Elomaa
Jul 21, 2001·Japanese Journal of Clinical Oncology·M KoizumiE Ogata
Jul 20, 2002·Annals of Nuclear Medicine·Mitsuru Koizumi, Etsuro Ogata
Aug 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Trevor PowlesLiisa Pylkkänen
Sep 10, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce E HillnerUNKNOWN American Society of Clinical Oncology
Sep 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas J Smith, UNKNOWN American Society of Clinical Oncology
Feb 28, 2007·British Journal of Cancer·T C Ha, H Li
Feb 14, 2009·The New England Journal of Medicine·Michael GnantC Marth
May 19, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R E Coleman
Feb 24, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Catherine H Van PoznakUNKNOWN American Society of Clinical Oncology

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Citations

Mar 8, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Roger von MoosCarsten Bokemeyer
Oct 24, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Asrin KarimiEzzatollah Rahimi
Dec 19, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Tohid Jafari-KoshkiFariborz Mokarian
Nov 27, 2014·Neoplasia : an International Journal for Oncology Research·Kosei NakajimaAvraham Raz

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

SPSS
StatXact

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