PMID: 11318882Apr 25, 2001Paper

An open-label dose-titration study of the efficacy and tolerability of tizanidine hydrochloride tablets in the prophylaxis of chronic daily headache

Headache
Joel R SaperAlvin E Lake

Abstract

To assess effectiveness and safety of tizanidine hydrochloride tablets for the prophylaxis of chronic daily headache. Tizanidine hydrochloride is an alpha2-adrenergic agonist that inhibits the release and effectiveness of norepinephrine at both central sites (eg, the locus ceruleus) and the spinal cord. It acts as a central muscle relaxant and has antinociceptive effects. Preliminary research and retrospective analyses have suggested efficacy in treatment of both chronic tension-type headache and chronic daily headache with migrainous features. Thirty-nine patients with more than 15 headache days per month (33 with migraine, 5 migrainous, 1 chronic tension-type) completed a 4-week baseline, with 31 completing a planned 12 weeks of treatment with tizanidine. Dosing was titrated from 2 mg at bedtime to a median daily dose of 14 mg (mean, 13.5; SD, 4.3; range, 4 to 20, divided over three doses per day) by treatment week 4. The overall headache index through week 12 (headache frequency x average intensity x duration) declined significantly (P<.00000002), with a corresponding increase in mean percentage improvement from 49% for weeks 1 through 4, to 65% for weeks 5 through 8, and 64% for weeks 9 through 12 (P<.0182). During weeks 9 ...Continue Reading

References

Oct 1, 1987·Neuropharmacology·T NabeshimaT Kameyama
Mar 1, 1988·The Journal of International Medical Research·H Berry, D R Hutchinson
Mar 1, 1988·Cephalalgia : an International Journal of Headache·F SorgeP Carrieri
Feb 1, 1987·Headache·N T MathewF Perez
Aug 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·T KameyamaS Yamada
Apr 1, 1994·Cephalalgia : an International Journal of Headache·V PfaffenrathW Fischer
Feb 1, 1996·Cephalalgia : an International Journal of Headache·J RothrockC Jackson
Nov 1, 1996·Archives of Neurology·R D'Alessandro
Apr 12, 2000·Headache·E L SpieringsP C Honkoop

❮ Previous
Next ❯

Citations

Nov 5, 2002·Current Pain and Headache Reports·John Claude Krusz
Apr 30, 2004·Current Pain and Headache Reports·Marcelo E BigalAlan M Rapoport
Oct 6, 2004·Current Treatment Options in Neurology·Marc E LenaertsJames R Couch
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jul 13, 2006·The Neurologist·Marcelo E Bigal, Richard B Lipton
Nov 23, 2006·Cephalalgia : an International Journal of Headache·A R GantenbeinH Isler
Feb 4, 2010·The American Journal of Chinese Medicine·Lisa Li-Chen HsiehAmy Ming-Fang Yen
Oct 16, 2014·Drugs & Aging·Stephanie Wrobel GoldbergBrian M Grosberg
Oct 5, 2006·Current Opinion in Anaesthesiology·H Smith, J Elliott
Mar 19, 2008·Expert Review of Neurotherapeutics·Giuseppe NappiGiorgio Sandrini
Apr 19, 2005·Headache·Elizabeth Loder, David Biondi
Oct 3, 2020·Best Practice & Research. Clinical Anaesthesiology·Ivan UritsOmar Viswanath

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.