An open-label tolerability and efficacy study of an aluminum sesquichlorohydrate topical foam in axillary and palmar primary hyperhidrosis

Dermatologic Therapy
Daniele InnocenziGiuseppe Micali

Abstract

Primary hyperidrosis (PH) is a disorder characterized by excessive eccrine sweat gland production that primarily involves the axillae as well as palms and soles. Common first-line topical treatment for PH consists of aluminum salts (AS) that act by physically blocking eccrine sweat gland ducts. However, primary irritant contact dermatitis is a common side effect of AS treatment. Recently, a new low-residue, thermophobic foam formulation containing 20% aluminum sesquichlorohydrate has been developed (Nidrox, Mipharm S.p.A.). To evaluate the local tolerability and efficacy of 20% aluminum sesquichlorohydrate foam in the treatment of axillary and palmar PH. Twenty subjects affected by PH were enrolled in a multicenter, open-label study. Local tolerability was evaluated by physicians assessing itching, burning, and skin irritation using a four-point score (from 0: no symptoms to 3: severe symptoms). Skin irritation was quantified with a visual score. Efficacy was assessed by means of Minor test score using a four-point score (range 0-3). The foam was applied to clean dry skin, every night during the first 2 weeks and three times a week during the following 2 weeks. Clinical evaluations were performed at baseline, at day 14 and at d...Continue Reading

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Citations

Feb 23, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tarik PurtulogluAlparslan Turan
Mar 21, 2017·The Journal of Dermatological Treatment·Jason E Sammons, Amor Khachemoune
Dec 23, 2017·Health Technology Assessment : HTA·Ros WadeNerys Woolacott
Sep 16, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J Wohlrab, B Kreft
Jul 14, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·I Hoorens, K Ongenae
Oct 5, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·C PagliarelloA Paradisi

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