An open-label trial of interpersonal psychotherapy in depressed patients with coronary disease

Psychosomatics
Diana KoszyckiF Lespérance

Abstract

High rates of depression have been reported in patients with coronary artery disease, and depression has been repeatedly shown to adversely affect cardiac morbidity and mortality. Despite these findings, little work has been devoted to evaluating effective antidepressant treatments for this subpopulation. This open-label trial assessed the efficacy and acceptability of interpersonal psychotherapy in depressed patients with stable coronary artery disease. Seventeen patients with coronary artery disease who met DSM-IV criteria for major depression received 12 weekly sessions of interpersonal psychotherapy. Outcome was assessed with the 17-item Hamilton Depression Rating Scale and the Beck Depression Inventory II. Ten patients received medication during the trial, and seven patients received interpersonal psychotherapy alone. The patients showed a significant reduction in scores on both the Hamilton depression scale and the Beck Depression Inventory II from baseline, with 53% of the patients meeting criteria for remission, as defined by scores of < or =7 and < or =14 on the Hamilton depression scale and the Beck Depression Inventory II, respectively. Medicated and unmedicated patients responded similarly to interpersonal psychothe...Continue Reading

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Citations

Mar 22, 2014·Depression Research and Treatment·M CeccariniG Castelnuovo
Jul 5, 2011·Explore : the Journal of Science and Healing·Sara L WarberMelvyn Rubenfire
Jul 2, 2009·Psychosomatics·Ellen L PoleshuckDonna E Giles
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Feb 26, 2010·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Yekta DowlatiKrista L Lanctôt

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