An open multicenter study of polyacrylamide hydrogel (Bulkamid®) for female stress and mixed urinary incontinence.

International Urogynecology Journal
Gunnar LoseTosson Safwat

Abstract

Polyacrylamide hydrogel (PAHG, Bulkamid®) is a promising urethral bulking agent. This multicenter study was carried out to evaluate safety and efficacy of Bulkamid® for female stress and mixed urinary incontinence. Submucosal injection of Bulkamid® was performed in 135 women with urinary incontinence (stress, 67; mixed, 68) followed for 12 months. Forty-seven had a reinjection (35%). At 12 months, the subjective response rate was 66%. Incontinence episodes/24 h and urine leakage g/24 h decreased significantly (from 3.0 to 0.7 and 29 g to 4 g, respectively). Additionally, the median International Consultation on Incontinence Questionnaire score was reduced to approximately 50%, and the overall quality of life visual analogue scale score was decreased significantly (from 72 to 20). Efficacy was very similar between patients with stress and mixed incontinence. Thirty treatment-related adverse events were registered. The most frequent was urinary tract infection (n = 10). No polyacrylamide hydrogel-specific adverse events were seen. Bulkamid® is an effective and safe bulking agent in women with stress or mixed incontinence.

Associated Clinical Trials

References

Oct 1, 1991·Reviews on Environmental Health·E A Smith, F W Oehme
Feb 22, 2002·Neurourology and Urodynamics·Paul AbramsUNKNOWN Standardisation Sub-committee of the International Continence Society
Sep 12, 2002·Chemical Reviews·Marcus J CaulfieldDavid H Solomon
Apr 25, 2003·Plastic and Reconstructive Surgery·Lise H ChristensenIvan Kebuladze
Jun 18, 2004·The Journal of Urology·Selahattin BedirDoğan Erduran
Jul 1, 2004·Neurourology and Urodynamics·Kerry AveryPaul Abrams
Oct 7, 2004·Plastic and Reconstructive Surgery·Elena ZariniMaurizio Nava
Jun 22, 2005·European Urology·Christopher R ChappleAbdul H Sultan
Aug 25, 2005·European Urology·Christopher R ChappleSimon Hill
Dec 6, 2005·International Urogynecology Journal and Pelvic Floor Dysfunction·María-Teresa Castillo-VicoRamón Carreras-Collado
Dec 13, 2005·International Urogynecology Journal and Pelvic Floor Dysfunction·Paulo C R PalmaNelson Rodrigues Netto
Aug 17, 2006·BJU International·Rodney A AppellSender Herschorn
Nov 15, 2006·International Urogynecology Journal and Pelvic Floor Dysfunction·Eric HurtadoRodney Appell
May 15, 2007·Plastic and Reconstructive Surgery·Gustavo BelloAndrus Lee
Jul 20, 2007·The Cochrane Database of Systematic Reviews·P E KeeganR Pickard
Jul 20, 2007·International Urogynecology Journal and Pelvic Floor Dysfunction·Ehab A ElzayatJacques Corcos
Dec 25, 2007·International Urogynecology Journal and Pelvic Floor Dysfunction·Annette KuhnMichel D Mueller
Jul 2, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Lise H ChristensenGunnar Lose
Jul 22, 2008·Neurourology and Urodynamics·Niels Klarskov, Gunnar Lose
Oct 22, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·Ph H ter MeulenPh E V A van Kerrebroeck

❮ Previous
Next ❯

Citations

May 18, 2013·Der Urologe. Ausg. A·H Loertzer, P Schneider
Jun 19, 2012·International Urogynecology Journal·Stefan MohrAnnette Kuhn
Feb 2, 2013·Archives of Gynecology and Obstetrics·Umberto Leone Roberti MaggioreSimone Ferrero
May 31, 2014·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·A BeraruP Costa
Aug 11, 2012·The Urologic Clinics of North America·Dani Zoorob, Mickey Karram
Dec 30, 2015·International Urogynecology Journal·Margrethe Foss HansenKim Oren Gradel
Oct 15, 2013·The Journal of Obstetrics and Gynaecology Research·Hannah G KrauseJudith T W Goh
May 8, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Alois MartanJan Krhut
Jul 27, 2015·International Urogynecology Journal·Anushuya Devi KasiStergios K Doumouchtsis
Jun 3, 2016·International Urogynecology Journal·Meghan A GriffinHumphrey O Atiemo
Mar 20, 2014·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Carlo Vecchioli-Scaldazza Vecchioli-ScaldazzaVincenzo Ferrara
Jan 16, 2015·Urologia·Francesco MarsonBruno Frea
May 9, 2019·Neurourology and Urodynamics·Ervin KocjancicÖmer Acar
Dec 25, 2010·Neurourology and Urodynamics·Altaf MangeraChristopher Chapple
Feb 26, 2019·Neurourology and Urodynamics·Sadiya M Hussain, Rhiannon Bray
Jan 25, 2020·Nature Reviews. Urology·Christopher J HillaryChristopher R Chapple
Aug 21, 2020·World Journal of Urology·Ciara M E DalyKaren L Guerrero
Feb 22, 2017·International Urogynecology Journal·Zain A SiddiquiShahzad Shah
Dec 15, 2020·Gynécologie, Obstétrique, Fertilité & Sénologie·G LamblinE Nohuz
Jan 8, 2021·Neurourology and Urodynamics·Torsten BroscheEric R Sokol
May 21, 2021·Neurourology and Urodynamics·Venetia HoeHelen E O'Connell
Jun 10, 2021·International Urogynecology Journal·Siv Svennevik MyhrHjalmar A Schiøtz

❮ Previous
Next ❯

Methods Mentioned

BETA
urine leakage

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.