PMID: 8606657Mar 18, 1996Paper

An open multicentre study of tropisetron for cisplatin-induced nausea and vomiting

The Medical Journal of Australia
I N OlverL L Pearson

Abstract

(i) To assess the efficacy and tolerability of tropisetron when used for acute and delayed cisplatin-induced emesis. (ii) To investigate whether dexamethasone added to tropisetron improves the control of emesis for patients who do not achieve a complete response to tropisetron alone. (iii) To assess sex of the patient and alcohol intake as prognostic factors for nausea and vomiting. A prospective open label phase II trial over one or two cycles of chemotherapy. Data collection was based on observed response and patients' self-reporting. Twenty Australian tertiary care hospitals in 1994. 102 male and female patients from 18 to 75 years with histologically confirmed malignancy receiving their first chemotherapy containing > or = 50 mg/m2 cisplatin. In Cycle 1 tropisetron 5 mg was given intravenously before chemotherapy on Day 1, then 5 mg orally before breakfast on Days 2 to 6. In Cycle 2, dexamethasone 20 mg intravenously on Day 1, then 8 mg orally on Days 2 to 6 could be added to tropisetron if a complete antiemetic response had not been achieved in Cycle 1. Number of vomiting episodes and severity of nausea for 6 days after chemotherapy; severity of side effects; patient satisfaction with chemotherapy treatment; oestradiol lev...Continue Reading

References

Jan 1, 1992·Drugs·K M de Bruijn
Apr 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F RoilaD Donati
Feb 1, 1991·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M TonatoA Del Favero
Sep 1, 1990·Clinical Oncology : a Journal of the Royal College of Radiologists·F RoilaA Del Favero
Oct 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M G KrisD P Kelsen
Jan 1, 1993·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M SchmidtK M de Bruijn

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