PMID: 9169247Jan 1, 1997Paper

An open pilot study of citalopram for behavioral disturbances of dementia. Plasma levels and real-time observations

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
B G PollockJ Rosen

Abstract

Citalopram, in European studies, has shown some early promise for treatment of poststroke depression and behavioral complications of dementia. An open pilot study of citalopram was conducted in 16 patients with dementia and behavioral disturbances. Citalopram was well tolerated by 13 of the patients, and 9 had a clinically impressive response. A significant overall mean reduction in disruptive vocalizations was observed by means of a novel technique of computer-assisted real-time observation. The mean citalopram plasma level-to-dose ratio was found to be twice that previously reported in younger patients. These pilot findings should encourage future placebo concentration-controlled trials.

Citations

Jul 12, 2002·International Journal of Geriatric Psychiatry·Krista L LanctôtClaudio A Naranjo
Jan 1, 2008·Research in Gerontological Nursing·Kim J CurytoDeedre K Vriesman
Nov 17, 2004·Journal of Clinical Pharmacology·Robert R BiesBruce G Pollock
Dec 24, 2014·La Presse médicale·Benjamin Calvet, Jean-Pierre Clément
Jan 8, 2004·Psychosomatics·Ondria C GleasonBruce G Pollock
Apr 26, 2011·Journal of the American Academy of Child and Adolescent Psychiatry·Hiwot WolduDavid Brent
Mar 19, 2003·Journal of Geriatric Psychiatry and Neurology·Fadi H RamadanRoger Prior
Feb 15, 2008·International Psychogeriatrics·Armin von GuntenBrigitte Schupbach
May 7, 1999·Journal of Geriatric Psychiatry and Neurology·B G Pollock, B H Mulsant
Dec 28, 2002·American Journal of Alzheimer's Disease and Other Dementias·Rita MorettiAntonio Bava
Jul 27, 2000·Journal of Geriatric Psychiatry and Neurology·K Y KimE Jones
Jul 27, 2000·Journal of Geriatric Psychiatry and Neurology·F H RamadanA G Bassanelli
Dec 24, 2018·British Journal of Clinical Pharmacology·Thitiporn SupasitthumrongSimon J C Davies
Nov 5, 2003·Expert Opinion on Pharmacotherapy·Hubert H FernandezBrian R Ott
Jul 3, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Margaret M Swanberg, Jeffrey L Cummings
Oct 28, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Tina MainkaChristos Ganos

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