An open port sampling interface for liquid introduction atmospheric pressure ionization mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
Gary J Van Berkel, Vilmos Kertesz

Abstract

A simple method to introduce unprocessed samples into a solvent for rapid characterization by liquid introduction atmospheric pressure ionization mass spectrometry has been lacking. The continuous flow, self-cleaning open port sampling interface introduced here fills this void. The open port sampling interface used a vertically aligned, co-axial tube arrangement enabling solvent delivery to the sampling end of the device through the tubing annulus and solvent aspiration down the center tube and into the ionization source of the mass spectrometer via the commercial APCI emitter probe. The solvent delivery rate to the interface was set to exceed the aspiration rate, creating a continuous sampling interface along with a constant, self-cleaning spillover of solvent from the top of the probe. Using the open port sampling interface with positive ion mode APCI and a hybrid quadrupole time-of-flight mass spectrometer, rapid, direct sampling and analysis possibilities are exemplified with plastics, ballpoint and felt tip ink pens, skin, and vegetable oils. These results demonstrated that the open port sampling interface could be used as a simple, versatile and self-cleaning system to rapidly introduce multiple types of unprocessed, some...Continue Reading

References

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May 28, 2014·Rapid Communications in Mass Spectrometry : RCM·Vilmos Kertesz, Gary J Van Berkel
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Nov 29, 2014·The Analyst·Priscila da Silva FerreiraEvandro Piccin

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Citations

Jul 25, 2019·Rapid Communications in Mass Spectrometry : RCM·Andrew D RayStephen W Holman
May 5, 2020·Natural Product Reports·Stephanie GalanieJames Lalonde
Oct 6, 2020·Metabolic Engineering·Matthew RienzoMichael D Leavell
Apr 24, 2021·Journal of Chromatography. a·Ibraam E MikhailMichael C Breadmore
Sep 13, 2017·Journal of the American Society for Mass Spectrometry·Kenneth D SwansonGary L Glish
Jul 23, 2021·Analytical Methods : Advancing Methods and Applications·Thomas P ForbesGreg Gillen
Jul 29, 2021·Analytical Chemistry·Hui ZhangMatthew D Troutman
Nov 13, 2020·Journal of the American Society for Mass Spectrometry·Courtney L WaltonJohn F Cahill
Mar 2, 2018·Analytical Chemistry·Anyin LiFacundo M Fernández
Aug 24, 2021·Analytical and Bioanalytical Chemistry·Sophie Bravo-Veyrat, Gérard Hopfgartner
Oct 21, 2020·Journal of the American Society for Mass Spectrometry·Haidy MetwallyRichard Oleschuk
Jan 21, 2017·Analytical Chemistry·Patricia M PeacockSarah Trimpin
Nov 19, 2021·Journal of Chemical Information and Modeling·Austin ClydeRick Stevens

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