An open prospective pilot study on the use of rapamycin after penetrating high-risk keratoplasty

Transplantation
Florian BirnbaumT Reinhard

Abstract

The purpose of this study was to prove efficacy and safety of systemic immunosuppression with rapamycin following penetrating high-risk keratoplasty. Rapamycin has shown its immunosuppressive potential in the rat keratoplasty model and is a component of several immunosuppressive protocols after solid organ transplantation. In this pilot study, we compared the efficacy and safety of rapamycin and mycophenolate mofetil (MMF). Ten patients (group 1) undergoing high-risk keratoplasty were included in this study, receiving rapamycin as postoperative immunoprophylaxis. Rapamycin was administered orally once daily (blood trough level 4-10 ng/ml) for 6 months. Thereafter, it was tapered over 2 weeks. The control group (group 2) consisted of 24 patients who received 1000 mg MMF twice daily for 6 months. All of the patients received postoperative medication with fluocortolone 1 mg/kg/day (tapered over 3 weeks) and prednisolone acetate eyedrops 5 times per day (tapered over 5 months). Mean follow-up of all patients (n=34) was 739 days. No immune reaction was observed in groups 1 and 2 during the first 6 months under immunosuppression. Two immune reactions occurred in group 1, and five in group 2 within a 2-year follow-up. All of the immun...Continue Reading

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Citations

Mar 24, 2007·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·F BirnbaumT Reinhard
Jun 25, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Svetlana StanojlovicUwe Pleyer
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Mar 19, 2014·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·T LappT Reinhard
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Apr 15, 2011·American Journal of Ophthalmology·Vincent M BorderieLaurent Laroche
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Nov 26, 2019·Transplantation·W John ArmitageBertrand Vabres
May 11, 2017·Chemical Biology & Drug Design·Xinyao LiuYan Zhang
Dec 2, 2020·International Journal of Molecular Sciences·Claudia M Trujillo-VargasCintia S de Paiva
Aug 7, 2020·Progress in Retinal and Eye Research·Chang Ho YoonMee Kum Kim

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