An open source software for analysis of dynamic contrast enhanced magnetic resonance images: UMMPerfusion revisited

BMC Medical Imaging
Frank G ZöllnerGerald Weisser

Abstract

Perfusion imaging has become an important image based tool to derive the physiological information in various applications, like tumor diagnostics and therapy, stroke, (cardio-) vascular diseases, or functional assessment of organs. However, even after 20 years of intense research in this field, perfusion imaging still remains a research tool without a broad clinical usage. One problem is the lack of standardization in technical aspects which have to be considered for successful quantitative evaluation; the second problem is a lack of tools that allow a direct integration into the diagnostic workflow in radiology. Five compartment models, namely, a one compartment model (1CP), a two compartment exchange (2CXM), a two compartment uptake model (2CUM), a two compartment filtration model (2FM) and eventually the extended Toft's model (ETM) were implemented as plugin for the DICOM workstation OsiriX. Moreover, the plugin has a clean graphical user interface and provides means for quality management during the perfusion data analysis. Based on reference test data, the implementation was validated against a reference implementation. No differences were found in the calculated parameters. We developed open source software to analyse DC...Continue Reading

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Citations

Dec 9, 2017·European Radiology·Johannes BudjanGregor Jost
Jan 24, 2017·Scientific Reports·Jakob Nikolas KatherFrank Gerrit Zöllner
Jan 18, 2017·Journal of Digital Imaging·Christopher J LangeMartin R Prince
Sep 22, 2017·Scientific Reports·Tanja GaaFrank G Zöllner
Sep 24, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sabrina Kahina BechChristoffer Laustsen

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Software Mentioned

UMMperfusion
OsiriX
OpossUMM
mpfit
OsiriX 4D viewer
PMI
DICOM
UMMPAlgorithmController
Grand Central Dispatch
Mac OSX

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