PMID: 9179634Jan 1, 1997Paper

An open study of the efficacy and adverse effects of moclobemide in patients with the chronic fatigue syndrome

International Clinical Psychopharmacology
P D White, K J Cleary

Abstract

There is a strong association between the chronic fatigue syndrome and both depressive illness and sleep disturbance, but the efficacy of antidepressants is uncertain. We studied the efficacy and adverse effects of moclobemide in patients with chronic fatigue syndrome, stratifying the sample both by co-morbid major depressive illness and by sleep disturbance. Forty-nine patients with chronic fatigue syndrome were recruited. Patients were given moclobemide up to 600 mg a day for 6 weeks. Four (8%) patients dropped out, three because of adverse effects. Adverse effects wee otherwise mild and transient. On analysing the whole sample, there were significant but small reductions in fatigue, depression, anxiety and somatic amplification, as well as a modest overall improvement. The greatest improvement occurred in those individuals who had a co-morbid major depressive illness, with seven out of 14 (50%) of such individuals rating themselves as "much better" by 6 weeks, compared to six out of 31 (19%) of those who were not depressed (31% difference, 95% CI 1-60%, P = 0.04). Sleep disturbance had no effect on outcome. Moclobemide may be indicated in patients with chronic fatigue syndrome and a co-morbid major depressive disorder. A ran...Continue Reading

Citations

Nov 8, 2011·Infectious Disease Clinics of North America·Hemda RosenblumHoward Amital
Jul 18, 2006·Psychosomatics·John W DenningerMaurizio Fava
Jan 18, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·George I Papakostas
Aug 1, 2003·Acta Neuropsychiatrica·Harald Murck
Sep 7, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jay D AmsterdamNancy Rutherford
May 21, 1999·The Australian and New Zealand Journal of Psychiatry·I Hickie
Jan 28, 2020·Current Treatment Options in Rheumatology·Courtney ShappleyLesley Ann Saketkoo
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