An optimized SPE-LC-MS/MS method for antibiotics residue analysis in ground, surface and treated water samples by response surface methodology- central composite design

Journal of Environmental Health Science & Engineering
Roya MirzaeiAlireza Mesdaghinia

Abstract

Antibiotic residues are being constantly identified in environmental waters at low concentration. Growing concern has been expressed over the adverse environmental and human health effects even at low concentration. Hence, it is crucial to develop a multi-residues analytical method for antibiotics to generate a considerable dataset which are necessary in the assessment of aquatic toxicity of environmental waters for aquatic organisms and human health. This work aimed to develop a reliable and sensitive multi-residue method based on high performance liquid chromatography coupled with quadrupole-linear ion trap tandem mass spectrometry (HPLC-MS-MS). The method was optimized and validated for simultaneous determination of four classes of antibiotics including, β-lactam, macrolide, fluoroquinolone and nitro-imidazole in treated, ground and surface water matrices. In order to optimize the solid phase extraction process, main parameters influencing the extraction process including, pH, the volume of elution solvent and the amount of Na4EDTA were evaluated. The optimization of extraction process was carried out by response surface methodology using central composite design. Analysis of variance was performed for nine target antibiotic...Continue Reading

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Citations

Oct 22, 2019·Preparative Biochemistry & Biotechnology·Olga Nehir OztelErdal Karaoz
Feb 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammad H SemreenKumud Acharya
Jan 30, 2021·Environmental Science and Pollution Research International·Samuel MolesRosa Mosteo
Feb 17, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Tien-Duc PhamThu-Ha Hoang
Jul 26, 2019·The Science of the Total Environment·Ngoc Han TranKarina Yew-Hoong Gin
Aug 17, 2021·The Science of the Total Environment·Jayakumar RenganathanLigy Philip
Oct 2, 2021·The Science of the Total Environment·Rui ZhangLiyan Song

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