An optofluidic metasurface for lateral flow-through detection of breast cancer biomarker

Biosensors & Bioelectronics
Yifei WangMeng Lu

Abstract

The rapid growth of point-of-care tests demands for biosensors with high sensitivity and small size. This paper demonstrates an optofluidic metasurface that combines silicon-on-insulator (SOI) nanophotonics and nanofluidics to realize a high-performance, lateral flow-through biosensor. The metasurface is made of a periodic array of silicon nanoposts on an SOI substrate, and functionalized with specific receptor molecules. Bonding of a polydimethylsiloxane slab directly onto the surface results in an ultracompact biosensor, where analyte solutions are restricted to flow only in the space between the nanoposts. No flow exists above the nanoposts. This sensor design overcomes the issue with diffusion-limited detection of many other biosensors. The lateral flow-through feature, in conjunction with high-Q resonance modes associated with optical bound states of the metasurface, offers an improved sensitivity to subtle molecule-bonding induced changes in refractive index. The device exhibits a resonance mode around 1550 nm wavelength and provides an index sensitivity of 720 nm/RIU. Biosensing is conducted to detect the epidermal growth factor receptor 2 (ErbB2), a protein biomarker for early-stage breast cancer screening, by monitorin...Continue Reading

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Citations

Nov 19, 2018·Biosensors & Bioelectronics·Gabriel Sancho-FornesÁngel Maquieira
Oct 31, 2020·Research : a Science Partner Journal·Ruitao LiuTianhong Cui
Jan 13, 2021·Sensors·Jia-Ming YangCheng-Sheng Huang
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Neda ShahbaziSeyed Morteza Naghib
Jan 19, 2021·ACS Biomaterials Science & Engineering·Zahra Mohammadpour, Keivan Majidzadeh-A

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