An Orbitide from Ratibida columnifera Seed Containing 16 Amino Acid Residues

Journal of Natural Products
Mark F FisherJoshua S Mylne

Abstract

Cyclic peptides are abundant in plants and have attracted interest due to their bioactivity and potential as drug scaffolds. Orbitides are head-to-tail cyclic peptides that are ribosomally synthesized, post-translationally modified, and lack disulfide bonds. All known orbitides contain 5-12 amino acid residues. Here we describe PLP-53, a novel orbitide from the seed of Ratibida columnifera. PLP-53 consists of 16 amino acids, four residues larger than any known orbitide. NMR structural studies showed that, compared to previously characterized orbitides, PLP-53 is more flexible and, under the studied conditions, did not adopt a single ordered conformation based on analysis of NOEs and chemical shifts.

References

Mar 1, 1991·Chemical & Pharmaceutical Bulletin·K KinoshitaT Kinoshita
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·C GonzálezM Rico
Jul 27, 2001·Nature·S Fernandez-LopezM R Ghadiri
Jan 5, 2002·Journal of Biomolecular NMR·T Cierpicki, J Otlewski
Sep 25, 2004·Journal of Natural Products·Alassane WéléBernard Bodo
Oct 27, 2005·Journal of the American Chemical Society·Mark V Berjanskii, David S Wishart
Mar 9, 2006·Chemical Reviews·Ning-Hua Tan, Jun Zhou
Mar 24, 2007·Journal of Natural Products·Erika SvangårdUlf Göransson
Nov 13, 2010·Journal of Natural Products·Junmian TianWeidong Zhang
May 11, 2011·The Plant Journal : for Cell and Molecular Biology·Janet A CondiePatrick S Covello
Oct 3, 2012·PloS One·Timo H J Niedermeyer, Martin Strohalm
Dec 18, 2013·Drug Discovery Today·Kathrin ThellChristian W Gruber
Jan 11, 2014·Biopolymers·Denis P Okinyo-OwitiMartin J T Reaney
Apr 1, 2014·The Plant Cell·Alysha G ElliottJoshua S Mylne
Nov 5, 2014·Plant Methods·Achala S JayasenaJoshua S Mylne
Nov 8, 2014·Molecular Biology and Evolution·Tunjung MahatmantoDavid J Craik
Feb 24, 2015·Journal of Natural Products·Meri Emili F PintoVanderlan S Bolzani
Apr 19, 2015·BMC Genomics·William R BelknapEd Stover
May 12, 2015·Chemistry & Biology·Kalia Bernath-LevinJoshua S Mylne
Nov 13, 2015·Journal of Natural Products·Priscila de M Cândido-BacaniWalmir S Garcez
Jan 16, 2016·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Achala S JayasenaJoshua S Mylne
Apr 16, 2016·Journal of Natural Products·Pâmela J Dos S BeirigoVirgínia C da Silva
Jun 30, 2016·Biopolymers·Bastian FrankeK Johan Rosengren
Oct 4, 2016·Amino Acids·Alysha G ElliottK Johan Rosengren
Mar 24, 2017·Molecular Biology and Evolution·Achala S JayasenaJoshua S Mylne
Nov 13, 2018·Plant Direct·Mark F FisherJoshua S Mylne
Feb 20, 2019·Frontiers in Chemistry·Evan F HaneyRobert E W Hancock

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Citations

Jul 4, 2020·Journal of Industrial Microbiology & Biotechnology·Garret M Rubin, Yousong Ding
Aug 21, 2020·The Journal of Biological Chemistry·Mark F FisherJoshua S Mylne
Feb 19, 2021·Medicinal Research Reviews·Jingjing ZhangChengchao Xu
Mar 6, 2021·Biochemical Society Transactions·Samuel G NonisJoshua S Mylne
Jun 23, 2021·Biochemical Society Transactions·Norelle L Daly, David T Wilson
Apr 3, 2020·Journal of Natural Products·Mark F FisherJoshua S Mylne
Oct 22, 2021·Journal of Natural Products·Colton D PayneK Johan Rosengren

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