An organic transistor-based system for reference-less electrophysiological monitoring of excitable cells

Scientific Reports
A SpanuAnnalisa Bonfiglio

Abstract

In the last four decades, substantial advances have been done in the understanding of the electrical behavior of excitable cells. From the introduction in the early 70's of the Ion Sensitive Field Effect Transistor (ISFET), a lot of effort has been put in the development of more and more performing transistor-based devices to reliably interface electrogenic cells such as, for example, cardiac myocytes and neurons. However, depending on the type of application, the electronic devices used to this aim face several problems like the intrinsic rigidity of the materials (associated with foreign body rejection reactions), lack of transparency and the presence of a reference electrode. Here, an innovative system based on a novel kind of organic thin film transistor (OTFT), called organic charge modulated FET (OCMFET), is proposed as a flexible, transparent, reference-less transducer of the electrical activity of electrogenic cells. The exploitation of organic electronics in interfacing the living matters will open up new perspectives in the electrophysiological field allowing us to head toward a modern era of flexible, reference-less, and low cost probes with high-spatial and high-temporal resolution for a new generation of in-vitro a...Continue Reading

References

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Citations

Dec 30, 2015·Analytical Chemistry·Tsukuru MinamikiShizuo Tokito
Jun 18, 2016·Scientific Reports·Eleonora MacchiaLuisa Torsi
Jul 26, 2016·Frontiers in Neuroscience·Paolo MassobrioSergio Martinoia
Jul 2, 2016·Chemical Reviews·Daniel T SimonMagnus Berggren
May 26, 2018·Scientific Reports·Fabrizio Antonio ViolaPiero Cosseddu
Oct 1, 2015·Angewandte Chemie·Kyriaki ManoliLuisa Torsi
Jul 6, 2018·Biosensors·Benoît PiroSteeve Reisberg
Nov 6, 2018·Sensors·Edoardo CantùMauro Serpelloni
May 10, 2019·APL Bioengineering·A SpanuA Bonfiglio
Nov 28, 2020·Advanced Functional Materials·Jong Seob ChoiDeok-Ho Kim
Apr 23, 2021·ACS Sensors·Mathew S ThomasKevin D Dorfman
Mar 7, 2018·The Journal of Physical Chemistry Letters·Mathew S ThomasC Daniel Frisbie
Dec 16, 2021·Chemical Reviews·Charalampos PitsalidisRóisín M Owens

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