An organoselenium drug with antioxidant activity and free radical scavenging capacity in vitro

Biological Trace Element Research
Mohammad IbrahimJoão Batista Teixeira Rocha

Abstract

Organoselenum compounds have been reported to have a wide range of pharmacological properties. Amine-based diselenide, (Z)-N-(4-methylbenzylidene)-1-(2-((2-(1-((E)-4-methyl benzylideneamino)ethyl)phenyl)diselanyl)phenyl)ethanamine ethyl)phenyl) diselanyl) phenyl) ethylimino) methyl)phenol (compound A), and diphenyl diselenide (PhSe)2 were screened for in vitro antioxidant activity. Compound A and (PhSe)2 were tested against sodium nitroprusside (SNP)- and Fe(II)-induced thiobarbituric acid-reactive species (TBARS) in rat brain homogenates. The radical scavenging activity was measured by 1,1-diphenyl-2-picrylhydrazyl assay. Both compounds A and (PhSe)2 decreased Fe(II)- and SNP-stimulated TBARS production in rat brain homogenates. Compound A exhibited the strongest antioxidant activity in the radical scavenging assay, although (PhSe)2, the simplest of the diaryl diselenide, presented no activity. In conclusion, the results of the present investigation indicated that compound A and (PhSe)2 had preventive effects against SNP- and Fe(II)-induced oxidative stress in rat brain homogenates. The amine group in the organic moiety dramatically changed the potency of amine-based diselenide.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jul 1, 1992·Archives of Biochemistry and Biophysics·J ChaudiereJ Leclaire
May 13, 1999·Biochimica Et Biophysica Acta·J P Bolaños, A Almeida
Apr 18, 2002·Neurochemical Research·J I RossatoJ B T Rocha
Dec 25, 2002·Free Radical Biology & Medicine·Hideaki ImaiIseabail Mhairi Macrae
Dec 9, 2004·Chemical Reviews·Cristina W NogueiraJoão B T Rocha
Jan 14, 2005·Molecular and Cellular Biochemistry·Marian ValkoJoshua Telser
Jun 30, 2006·Journal of Neurochemistry·Barry Halliwell
Apr 1, 2008·Experimental Biology and Medicine·Zeliha Selamoglu TalasIbrahim Orun
Nov 1, 2008·Biological Trace Element Research·Zeliha Selamoglu TalasBekir Cetinkaya
Mar 10, 2009·Biochimica Et Biophysica Acta·Holger Steinbrenner, Helmut Sies

❮ Previous
Next ❯

Citations

Aug 26, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Isaac A AdedaraJoao B T Rocha
Apr 18, 2015·Chembiochem : a European Journal of Chemical Biology·Michio IwaokaK Indira Priyadarsini
Apr 5, 2019·BMC Complementary and Alternative Medicine·Mohammad IbrahimJoao Batista Teixeira Rocha
Apr 2, 2021·Archives of Toxicology·Cristina W NogueiraJoão B T Rocha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.