PMID: 8592048Oct 1, 1995Paper

An original perifollicular zone cell in the canine reactive lymph node: a morphological, phenotypical and aetiological study

Journal of Comparative Pathology
C FournelP Felman

Abstract

In this study of 109 canine reactive lymph nodes, the perifollicular zone (PZ) cell was characterized by cytological, histological, immunocytochemical and electron microscopical techniques. The PZ cell was always found in association with plasma cell hyperplasia. Its main cytological characteristics were medium size, fine chromatin and a large central prominent nucleolus with a small amount of pale cytoplasm. It was located in a clearly recognizable PZ surrounding the follicles; this zone was particularly well developed at the capsular pole of the lymph node. Electron microscopical findings indicated a poorly differentiated cell. Immunolabelling indicated a CD3-, cIg-, Ki-67- immunophenotype, suggesting a resting B cell. These results suggest that the PZ cell belongs either to a post-follicular stage between large immunoblasts and plasma cells or, as is more likely, to a pre-follicular lymphoid subpopulation occurring early in the B-cell differentiation scheme, as with most human marginal zone (MZ) cells. Its high frequency of occurrence in reactive lymph nodes in mammary tumour lymphadenopathies, systemic lupus erythematosus and leishmaniasis, suggests that the PZ cell has a special role in the canine immune response, or perha...Continue Reading

References

Jan 1, 1992·Immunology Today·Y J LiuI C MacLennan
Sep 1, 1991·The American Journal of Surgical Pathology·N L Harris
Jan 1, 1990·Current Topics in Microbiology and Immunology·I C MacLennanP J Lane
Aug 1, 1990·Cancer·P G GreenleeP H Lieberman
Oct 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B FaliniL Lanfrancone
Jul 1, 1989·The Veterinary Clinics of North America. Small Animal Practice·J N Mills
Mar 1, 1988·The Journal of Experimental Medicine·D Gray
Nov 3, 1988·Nature·D Gray, H Skarvall
Dec 3, 1987·The New England Journal of Medicine·M D Cooper
May 1, 1987·Histopathology·P G Isaacson, J Spencer
Oct 1, 1986·American Journal of Clinical Pathology·J J van den OordV J Desmet
Jan 1, 1970·American Journal of Physical Anthropology·A AdamE Tabani
Jul 1, 1981·Veterinary Pathology·V E ValliJ H Lumsden
Dec 1, 1993·Veterinary Parasitology·A Martínez-MorenoS Hernández-Rodríguez
Mar 1, 1994·American Journal of Clinical Pathology·Y O HuhM J Keating
Jan 1, 1990·Leukemia & Lymphoma·S P Mulligan
Jan 1, 1987·Immunology Today·H Zola

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