An outbreak of Leishmania major from an endemic to a non-endemic region posed a public health threat in Iraq from 2014-2017: Epidemiological, molecular and phylogenetic studies

PLoS Neglected Tropical Diseases
Mariwan M M Al-BajalanHirotomo Kato

Abstract

Cutaneous leishmaniasis (CL) is a neglected worldwide, zoonotic, vector-borne, tropical disease that is a threat to public health. This threat may spread from endemic to non-endemic areas. Current research has exploited epidemiological, molecular and phylogenetical studies to determine the danger of an outbreak of CL in the borderline area between northern and central Iraq from 2014-2017. For the first time, using sequence analysis of the cytochrome b gene, the occurrence of CL in the borderline area between northern and central Iraq was confirmed to be due to Leishmania major. The phylogenetic analysis indicated that it was closely related to the L. major MRHO/IR/75/ER strain in Iran. In conclusion, the genotype confirmation of the L. major strain will improve our understanding of the epidemiology of the disease. This is important for facilitating control programs to prevent the further spread of CL. Furthermore, this area could be considered as a model for further research on the risk of global CL epidemics in other non-endemic countries where both reservoir hosts and sandfly vectors are present.

References

Dec 1, 1979·Annals of Tropical Medicine and Parasitology·M B RassamM L Chance
Jul 1, 2004·Comparative Immunology, Microbiology and Infectious Diseases·P Desjeux
Nov 26, 2005·International Journal for Parasitology·Jan M SchwenkenbecherGabriele Schönian
Sep 17, 2009·Journal of Infection in Developing Countries·Abdulghani Mohamad AlSamarai, Hussein Saher AlObaidi
Jun 14, 2012·PloS One·Jorge AlvarUNKNOWN WHO Leishmaniasis Control Team
Jun 10, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Homa HajjaranSaied Reza Naddaf
Oct 3, 2014·PLoS Neglected Tropical Diseases·Nasir SalamArezki Azzi
Nov 22, 2014·Nucleic Acids Research·Dennis A BensonEric W Sayers
Sep 24, 2015·Acta Tropica·Norbert Georg SchwarzHagen Frickmann
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
May 7, 2016·Acta Tropica·Mostafa GholamrezaeiMohammad Reza Shirzadi
Jun 9, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·A Al-JawabrehZ Abdeen
Oct 22, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Reza Fotouhi-ArdakaniParviz Parvizi
Feb 17, 2017·Parasites & Vectors·Dietmar Steverding

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Datasets Mentioned

BETA
MF-370217-MF-370223

Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

CLUSTAL W
Landsatlook viewer
Bankit
GraphPad
MEGA ( Molecular Evolutionary Genetics Analysis )
GraphPad Prism
CodonCode Aligner
MEGA

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