An outbreak of Mycoplasma pneumoniae caused by a macrolide-resistant isolate in a nursery school in China.

Antimicrobial Agents and Chemotherapy
Yong WangHongbin Song

Abstract

Eighteen out of 45 children were reported to have a respiratory illness during an outbreak at a temporary dormitory in a nursery school in China in 2011. To study the outbreak and to determine the risk factors for infection, an epidemiological investigation was performed. A standardized questionnaire was completed for a total of 45 children with the help of their guardians and parents. In addition, acute- and convalescent-phase serum samples and throat swabs from the children were taken for laboratory diagnosis. The diagnosis of a Mycoplasma-like illness was based on the following clinical criteria. The criteria were onset of illness after 31 May 2011, characterized by a cough, fever(>37.5 °C), or at least 3 of the following symptoms: fever, sore throat, cough or expectoration, and runny or stuffy nose. PCR-restriction fragment length polymorphism (PCR-RFLP), determination of MICs, and sequencing were performed to determine the genotype, antibiotic resistance, and sequence polymorphisms of the isolated strains, respectively. The paired sera revealed that 15 patients were infected with Mycoplasma pneumoniae. Epidemiology confirmed that this was a point source outbreak, characterized by a short incubation period, a high secondary...Continue Reading

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Citations

Sep 14, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cécile Bébéar
Nov 2, 2012·The Pediatric Infectious Disease Journal·Yu SuzukiYoko Matsuzaki
Apr 30, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Naoyuki MiyashitaNiro Okimoto
Aug 24, 2013·Journal of Clinical Microbiology·Victoria TsaiKenneth L Soyemi
May 11, 2016·Antimicrobial Agents and Chemotherapy·Yingshuo WangZhimin Chen
May 26, 2017·Clinical Microbiology Reviews·Ken B WaitesT Prescott Atkinson
Oct 13, 2018·The Science of the Total Environment·Zhaoyang YanShuangyang Ding

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