An overlapping syndrome of IgA nephropathy and membranous nephropathy?

Nephron
T DoiY Hamashima

Abstract

This is the first report of primary glomerular disease with both mesangial IgA and subepithelial IgG deposits in the glomeruli at the same time. This nephropathy, discovered in 3 patients, is either a new disease entity or an overlapping of IgA nephropathy and membranous nephropathy. Follow-up studies may clarify the pathogenesis of IgA nephropathy and/or membranous nephropathy. In 1 patient the clinical findings resembled those of IgA nephropathy, and in the other 2 they were those of membranous nephropathy. Light microscopy showed generalized diffuse increases in mesangial cells and matrix, and there was slight capillary wall thickening. In the glomeruli, immunofluorescence microscopy demonstrated both granular deposits of IgA in the mesangium and granular deposits of IgG along the capillary loops. On electron microscopy, electron-dense deposits were identified not only in the mesangium but also on the epithelial side of the glomerular basement membrane. These findings were confirmed by the immunoperoxidase technique in electron-microscopic studies of these antibody classes. These glomeruli contained both the dense reaction products of IgA deposits in the paramesangium and mesangial matrix and the dense reaction products of I...Continue Reading

Citations

Nov 17, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hae Il CheongYong Choi
Mar 1, 1986·The American Journal of Medicine·J D Heironimus, E L Perry
Mar 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T BertaniG Remuzzi
Feb 1, 1992·Kidney International·S Wakai, A B Magil
Sep 1, 1985·Acta Pathologica Japonica·Y KobayashiX M Chen
Jan 5, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kenichi MiyazakiShigeru Kohno
Jul 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·A LaasonenA Pasternack

Related Concepts

Basement Membrane
Bright Disease
IgA2
IgG2B
Peroxidase-Antiperoxidase Complex Technique
Kidney Diseases
Kidney Glomerulus
Electron Microscopy

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