An Overview of Chromatin-Regulating Proteins in Cells.

Current Protein & Peptide Science
Pingyu ZhangRaphael E Pollock

Abstract

In eukaryotic cells, gene expressions on chromosome DNA are orchestrated by a dynamic chromosome structure state that is largely controlled by chromatin-regulating proteins, which regulate chromatin structures, release DNA from the nucleosome, and activate or suppress gene expression by modifying nucleosome histones or mobilizing DNA-histone structure. The two classes of chromatinregulating proteins are 1) enzymes that modify histones through methylation, acetylation, phosphorylation, adenosine diphosphate-ribosylation, glycosylation, sumoylation, or ubiquitylation and 2) enzymes that remodel DNA-histone structure with energy from ATP hydrolysis. Chromatin-regulating proteins, which modulate DNA-histone interaction, change chromatin conformation, and increase or decrease the binding of functional DNA-regulating protein complexes, have major functions in nuclear processes, including gene transcription and DNA replication, repair, and recombination. This review provides a general overview of chromatin-regulating proteins, including their classification, molecular functions, and interactions with the nucleosome in eukaryotic cells.

Citations

Nov 9, 2017·International Journal of Molecular Sciences·Diletta Edifizi, Björn Schumacher
May 30, 2020·Journal of Cancer Research and Clinical Oncology·Luisa BergerSusanne Beyer
Jun 5, 2020·International Journal of Molecular Sciences·Sung Kyung ChoiJueng Soo You
Sep 28, 2017·Stem Cells and Development·Dandan DouLiang Hu
Oct 17, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Saurabh Pandey, Erle S Robertson
May 21, 2020·International Journal of Molecular Sciences·Nair LopesCarmen Jerónimo
Feb 11, 2021·The Biochemical Journal·Bethany C Taylor, Nicolas L Young
Oct 23, 2020·Molecular Biology Reports·Daiane Teixeira de Oliveira, Renata Guerra-Sá
Oct 30, 2020·Stem Cell Research & Therapy·Mahsa GhorbaninejadMohamadreza Baghaban Eslaminejad
Mar 4, 2021·Ageing Research Reviews·Elena G PasyukovaAlexander M Vaiserman
Jan 26, 2017·Neurobiology of Learning and Memory·Thekla J HemstedtMarcelo A Wood
Apr 4, 2021·International Journal of Molecular Sciences·Wasitha P D Wass ThilakarathnaNeale D Ridgway
Oct 16, 2020·Cancer Prevention Research·Rasika HudlikarAh-Ng Kong
Dec 29, 2020·Free Radical Biology & Medicine·Renyi WuAh-Ng Kong
May 18, 2021·Planta medica·Kasimu Ghandi IbrahimMustapha Umar Imam
May 19, 2021·Journal of Viral Hepatitis·Ferhat ArslanPasquale Pagliano
May 30, 2021·Experimental & Molecular Medicine·Pui Kei MouJoong Sup Shim
Jun 8, 2021·Frontiers in Cellular Neuroscience·Justine MathouxGary P Brennan
Aug 24, 2021·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Niels VelthuijsColin Logie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Sheng li ke xue jin zhan [Progress in physiology]
Xin-Rong XingHui-Jian Wu
Current Protein & Peptide Science
Ruilin WangMeixia Zhang
Critical Reviews in Eukaryotic Gene Expression
T Owen-Hughes, J L Workman
Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
K Luger
© 2022 Meta ULC. All rights reserved