An overview of conditioning regimens for haploidentical stem cell transplantation with post-transplantation cyclophosphamide

American Journal of Hematology
Munira Shabbir-MoosajeeStefan O Ciurea

Abstract

Haploidentical related donors are an attractive alternative source of stem cells for allogeneic stem cell transplantation due to widespread availability and ease of stem cell procurement. Historically, haploidentical stem cell transplantation (HaploSCT) with extensive T-cell depletion has been associated with high rates of infectious complications and nonrelapse mortality (NRM). Post-transplantation cyclophosphamide (PTCy) has been shown to induce immune tolerance, effectively control graft-versus-host-disease (GVHD), and is associated with lower NRM, making it a preferred option for patients undergoing HaploSCT. Over the last decade, several groups investigated PTCy for GVHD prevention in HaploSCT; it is now successfully utilized with both myeloablative and nonmyeloablative conditioning regimens with survival comparable to HLA-matched transplantation. Future directions will focus on optimizing conditioning regimens by diagnosis, improving donor selection, and enhancing graft-versus-leukemia effect.

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Citations

Mar 8, 2016·Advances in Hematology·Mohammad Faizan Zahid, David Alan Rizzieri
Apr 14, 2016·Journal of Hematology & Oncology·Ying-Jun ChangXiao-Jun Huang
Sep 14, 2016·European Journal of Haematology·Lucia SillaNelson Hamerschlak
Dec 17, 2016·Revista da Associação Médica Brasileira·Nelson Hamerschlak
May 9, 2018·Cell Transplantation·Tang-Her JaingPei-Kwei Tsay
Mar 24, 2020·Bone Marrow Transplantation·Seitaro TerakuraUNKNOWN Nagoya Blood and Marrow Transplantation Group

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