An overview of epidermal lamellar bodies: Novel roles in biological adaptations and secondary barriers

Journal of Dermatological Science
G K MenonSeung-Hun Lee

Abstract

The epidermal lamellar bodies (LBs) are specialized organelles that contain pro-barrier lipids imparting a fully lamellar internal structure, but also other cargoes such as enzymes (lipid metabolizing and proteolytic), enzyme inhibitors, and antimicrobial peptides. Thus, the LB secretory system, by virtue of delivering these cargoes to the stratum corneum (SC) interstices, is essential for forming the various skin barriers located in the SC. Ultrastructural studies have suggested that the morphologic features of LBs reflect the functional status of the SC. Several ichthyotic skin diseases as well as experimental animal models with defective epidermal lipogenesis show only partial lamellar contents or even empty appearing LB, reflecting an abnormal cargo composition. We suggest that LB polymorphism reflects a wide array of barrier adaptations to environmental challenges, rather than just a defective barrier function, based on observations on a) LB morphology in inherited skin disorders of lipid metabolism (Refsum disease, Chanarin-Dorfman syndrome) characterized by deficiency of lamellar lipids and accumulation of toxic metabolites; b) Psoriasis (with a high expression of Psoriasin antimicrobial peptide within lesions) and c) th...Continue Reading

Citations

Mar 10, 2020·Investigative Ophthalmology & Visual Science·Yang LiuDavid A Sullivan
Jan 11, 2020·Frontiers in Immunology·Margaret CoatesAmanda S MacLeod
Oct 22, 2019·Journal of Morphology·Gopinathan K MenonElizabeth A Mauldin
Feb 8, 2020·Nature Reviews. Endocrinology·Daniel Bikle, Sylvia Christakos
Feb 16, 2021·Frontiers in Pediatrics·Thulja TrikamjeeGian Vincenzo Zuccotti
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Sarmistha Mahanty, Subba Rao Gangi Setty

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