An Overview of Genome-Wide Association Studies in Alzheimer's Disease

Neuroscience Bulletin
Luxi Shen, Jianping Jia

Abstract

Genome-wide association studies (GWASs) have revealed a plethora of putative susceptibility genes for Alzheimer's disease (AD). With the sole exception of the APOE gene, these AD susceptibility genes have not been unequivocally validated in independent studies. No single novel functional risk genetic variant has been identified. In this review, we evaluate recent GWASs of AD, and discuss their significance, limitations, and challenges in the investigation of the genetic spectrum of AD.

References

Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Sep 13, 1996·Science·N Risch, K Merikangas
Aug 30, 2001·Trends in Genetics : TIG·D E Reich, E S Lander
Oct 11, 2001·American Journal of Human Genetics·H H GöringJ Blangero
Feb 8, 2006·Archives of General Psychiatry·Margaret GatzNancy L Pedersen
Jul 19, 2006·Human Molecular Genetics·Yonghong LiAlison Goate
Jan 16, 2007·Nature Genetics·Ekaterina RogaevaPeter St George-Hyslop
Jun 8, 2007·Neuron·Eric M ReimanDietrich A Stephan
Jun 19, 2007·Nature Genetics·Jonathan MarchiniPeter Donnelly
May 2, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·S E PodusloS Smith
May 30, 2008·Nature Genetics·Walter Bodmer, Carolina Bonilla
Oct 1, 2008·BMC Medical Genomics·Richard AbrahamGeorge Kirov
Jan 3, 2009·American Journal of Human Genetics·Gary W BeechamMargaret A Pericak-Vance
Jan 13, 2009·Nature Genetics·Minerva M CarrasquilloSteven G Younkin
Oct 9, 2009·Nature·Teri A ManolioPeter M Visscher
Feb 23, 2010·NeuroImage·Jason L SteinUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 20, 2010·Alzheimer's Research & Therapy·Nilüfer Ertekin-Taner
May 13, 2010·JAMA : the Journal of the American Medical Association·Sudha SeshadriUNKNOWN EADI1 Consortium
May 19, 2010·Nature Reviews. Genetics·Evan E EichlerJoseph H Nadeau
Jun 19, 2010·Archives of Neurology·Alessandro BiffiUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Jun 22, 2010·Nature Genetics·Jian YangPeter M Visscher
Jun 25, 2010·PloS One·Joshua M ShulmanPhilip L De Jager
Oct 12, 2010·BMC Neurology·Mi-Ryung HanUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 20, 2010·Neuron·Lars BertramRudolph E Tanzi
Nov 26, 2010·Journal of Alzheimer's Disease : JAD·Richard ShervaLindsay A Farrer
Dec 3, 2010·Neurology·S KimUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 12, 2011·Current Psychiatry Reports·Richard Sherva, Lindsay A Farrer

❮ Previous
Next ❯

Citations

May 17, 2017·Journal of Alzheimer's Disease : JAD·Jin-Bao ZhuJin-Tai Yu
Jul 2, 2017·Molecular Biology and Evolution·Mizuka Sekine, Takashi Makino
Nov 28, 2017·Neuroscience Bulletin·Qiujian Yu, Chunjiu Zhong
Oct 6, 2018·Journal of Neurochemistry·K W LiAugust B Smit
Dec 4, 2019·Topics in Magnetic Resonance Imaging : TMRI·Luke W BonhamJennifer S Yokoyama
Oct 11, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·S BarralY Stern
Apr 25, 2020·Journal of Personalized Medicine·Valeria D'Argenio, Daniela Sarnataro
Apr 19, 2020·Annals of Biomedical Engineering·Jessica S SadickEric M Darling
Oct 6, 2020·Journal of Alzheimer's Disease : JAD·Aziz M MezliniSudeshna Das
Mar 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jordan H CaterAmy R Wyatt
Aug 21, 2019·Oxidative Medicine and Cellular Longevity·Jordan H CaterAmy R Wyatt
Jun 6, 2019·Human Genetics·Emmanuelle Génin
Nov 13, 2018·Neuroscience Bulletin·Mei-Hong LuQuan-Hong Ma
Feb 9, 2021·Reviews in the Neurosciences·Asiamah Ernest AmponsahHuixian Cui
Jan 31, 2021·International Journal of Molecular Sciences·Anna YangOrnit Chiba-Falek
Oct 28, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sajini D HettiarachchiRoger M Leblanc
Mar 21, 2021·NPJ Systems Biology and Applications·Seonggyun HanYounghee Lee
Jul 20, 2020·Ageing Research Reviews·Amalia C BruniCarlo Gabelli
Jul 25, 2021·Molecular Neurodegeneration·Christel ClaesMathew Blurton-Jones
Nov 25, 2020·Current Gene Therapy·Md Sahab UddinGhulam Md Ashraf

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.