An overview of measuring impulsive behavior in mice

Current Protocols in Mouse Biology
Claire L Dent, Anthony R Isles

Abstract

Impulsive behavior is a key constituent of many psychiatric illnesses, with maladaptive response control being a feature of disorders such as ADHD, schizophrenia, mania, and addiction. In order to understand the neurological underpinnings of impulsivity, a number of behavioral tasks have been developed for use with animal models. Data from studies with rats and other animals have led to the idea of the existence of dissociable components of impulsivity, which in turn informs studies of human disorders and potentially the development of specific therapies. Increasingly, mouse models are being used to investigate the known genetic contribution to psychiatric disorders in which abnormal response control leads to altered impulsive behaviors. In order to maximize the potential of these mouse models, it is important that researchers take into account the non-unitary nature of response control and impulsivity. In this article, we briefly review the tasks available to behavioral neuroscientists and how these can be used in order to tease apart the contribution of a specific genetic lesion into the discrete aspects of impulsive behavior.

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Citations

Mar 22, 2019·Journal of Medical Internet Research·Karen Frydenrejn FunderskovKarin Brochstedt Dieperink
Jul 23, 2019·Journal of Leukocyte Biology·Fernanda P B NunesMomtchilo Russo
Apr 18, 2015·Case Reports in Dentistry·Vanja Vucicevic BorasDanko Velimir Vrdoljak
Aug 11, 2016·Genes, Brain, and Behavior·C L DentA R Isles
Mar 2, 2021·Frontiers in Neuroscience·Linda TsanScott E Kanoski

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